Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 4/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3149015 | 0.76 | MTNR1A (0.41) | MTNR1AMTNR1BAKR1C2POLBTDP1 | |
| SCHEMBL14487776 | 0.72 | MTNR1A (0.63) | MTNR1AMTNR1BRAF1DYRK1APOLB | |
| SCHEMBL16711956 | 0.71 | MTNR1A (0.53) | MTNR1AMTNR1BRAF1DYRK1APOLB | |
| SCHEMBL3158506 | 0.70 | PTGS2 (0.54) | MTNR1AMTNR1BAKR1C2PTGDR2POLB | |
| SCHEMBL15548752 | 0.69 | POLB (0.44) | MTNR1AMTNR1BAKR1C2PTGDR2POLB | |
| SCHEMBL19193588 | 0.68 | KDM4E (0.44) | MTNR1AMTNR1BAKR1C2RAF1DYRK1A | |
| SCHEMBL4224000 | 0.67 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL2768796 | 0.67 | SMN1; SMN2 (0.40) | POLBTDP1GAAKDM4EMAPT | |
| SCHEMBL15242249 | 0.65 | MTNR1A (0.67) | MTNR1AMTNR1BPOLBKDM4EMAPT | |
| SCHEMBL9588551 | 0.65 | CYP1A2 (0.43) | AKR1C2PTGDR2POLBTDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943493-B1 | THERAPEUTIC COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS | GILEAD SCIENCES INC (US) | 2017-08-02 | — | — | EP | disclosed |
| EP-2943493-B1 | THERAPEUTIC COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS | GILEAD SCIENCES INC (US) | 2017-08-02 | — | — | EP | disclosed |
| EP-2943493-A1 | THERAPEUTIC COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS | Gilead Sciences, Inc. (US) | 2015-11-18 | — | — | EP | disclosed |
| US-9012441-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-04-21 | — | — | US | disclosed |
| US-9012441-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-04-21 | — | — | US | disclosed |
| US-20140221417-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140221417-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| WO-2014110296-A1 | THERAPEUTIC COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2014-07-17 | — | — | WO | disclosed |
| WO-2014110296-A1 | THERAPEUTIC COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2014-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221417-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, G6PD | MTNR1A 3693/4885MTNR1B 3184/4885AKR1C2 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.