Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17131458 | 0.84 | GAA (0.43) | GAAPAOXPOLBTSHRALDH1A1 | |
| SCHEMBL12128836 | 0.84 | GAA (0.43) | GAAPAOXPOLBTSHRALDH1A1 | |
| SCHEMBL2181054 | 0.79 | PAOX (0.47) | GAAPAOXTSHRKDM4EMEN1 | |
| SCHEMBL4637391 | 0.79 | ANPEP (0.52) | GAAPOLBALDH1A1MAPTMEN1 | |
| SCHEMBL7288389 | 0.78 | ANPEP (0.56) | GAATSHRALDH1A1KDM4EGLA | |
| SCHEMBL10098488 | 0.74 | KMT2A (0.41) | GAAPAOXPOLBTSHRALDH1A1 | |
| SCHEMBL16103625 | 0.74 | KMT2A (0.41) | GAAPAOXPOLBTSHRALDH1A1 | |
| SCHEMBL5668078 | 0.73 | GAA (0.42) | GAAPAOXPOLBTSHRALDH1A1 | |
| SCHEMBL14385187 | 0.73 | SIGMAR1 (0.38) | GAAPAOXPOLBTSHRALDH1A1 | |
| SCHEMBL27903589 | 0.72 | TP53 (0.35) | GAAPOLBTSHRKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9248131-B2 | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150224108-A1 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE | UNIV ARIZONA STATE (US) | 2015-08-13 | — | — | US | disclosed |
| US-8835491-B2 | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2014-09-16 | — | — | US | disclosed |
| EP-2086329-B1 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE | UNIV ARIZONA STATE (US) | 2014-07-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150224108-A1 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE | AQP1, AQP4, AQP3 | GAA 3940/4885PAOX 907/4885POLB 4599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.