Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GALK1 | P51570 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313390 | 0.93 | ALDH1A1 (0.46) | PTGS2ALDH1A1HSD17B10TDP1CYP2A6 | |
| SCHEMBL31194215 | 0.83 | PTGS2 (0.46) | PTGS2ALDH1A1HSD17B10TDP1CYP2A6 | |
| SCHEMBL4202592 | 0.83 | PTGS2 (0.55) | PTGS2ALDH1A1PTGS1MAPTRAB9A | |
| SCHEMBL8196670 | 0.83 | ALDH1A1 (0.61) | PTGS2ALDH1A1HSD17B10TDP1CYP2A6 | |
| SCHEMBL5711493 | 0.82 | PTGS2 (0.52) | PTGS2ALDH1A1HSD17B10CYP2A6PTGS1 | |
| SCHEMBL2007711 | 0.82 | PTPRC (0.44) | PTGS2ALDH1A1HSD17B10TDP1PTGS1 | |
| SCHEMBL5682823 | 0.82 | CA12 (0.42) | PTGS2ALDH1A1HSD17B10TDP1MEN1 | |
| SCHEMBL2008147 | 0.82 | PTGS2 (0.53) | PTGS2ALDH1A1PTGS1MEN1NPC1 | |
| SCHEMBL17628496 | 0.82 | ALDH1A1 (0.40) | PTGS2ALDH1A1HSD17B10TDP1CYP2A6 | |
| SCHEMBL27691428 | 0.80 | ALDH1A1 (0.48) | PTGS2ALDH1A1HSD17B10TDP1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376382-B2 | N-substituted isopropyldimethyl azulene sulfonamide derivatives, and preparation method and use thereof | SICHUAN GUOKANG PHARMACEUTICAL CO., LTD. (CN) | 2016-06-28 | — | — | US | claimed |
| US-20140206741-A1 | N-SUBSTITUTED ISOPROPYLDIMETHYL AZULENE SULFONAMIDE DERIVATIVES, AND PREPARATION METHOD AND USE THEREOF | SICHUAN GUOKANG PHARMACEUTICAL CO., LTD (CN) | 2014-07-24 | — | — | US | claimed |
| CN-119528772-A | Preparation method of azulene sulfonamide | 山东华素制药有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119528772-A | Preparation method of azulene sulfonamide | 山东华素制药有限公司 | 2025-02-28 | — | — | CN | disclosed |
| US-9376382-B2 | N-substituted isopropyldimethyl azulene sulfonamide derivatives, and preparation method and use thereof | SICHUAN GUOKANG PHARMACEUTICAL CO., LTD. (CN) | 2016-06-28 | — | — | US | disclosed |
| US-20140206741-A1 | N-SUBSTITUTED ISOPROPYLDIMETHYL AZULENE SULFONAMIDE DERIVATIVES, AND PREPARATION METHOD AND USE THEREOF | SICHUAN GUOKANG PHARMACEUTICAL CO., LTD (CN) | 2014-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140206741-A1 | N-SUBSTITUTED ISOPROPYLDIMETHYL AZULENE SULFONAMIDE DERIVATIVES, AND PREPARATION METHOD AND USE THEREOF | GIPR, SSTR5, STS | PTGS2 382/4885ALDH1A1 244/4885HSD17B10 2008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.