Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 19/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | DRD2 | P14416 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 2/20 | 0.63 |
| ▸ | HTR2C | P28335 | 2/20 | 0.63 |
| ▸ | HTR2B | P41595 | 2/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436502 | 0.83 | SIGMAR1 (0.56) | SIGMAR1 | |
| SCHEMBL8553726 | 0.83 | SIGMAR1 (0.56) | SIGMAR1 | |
| SCHEMBL466954 | 0.80 | SIGMAR1 (1.00) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19828185 | 0.78 | SIGMAR1 (0.33) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29793198 | 0.78 | SIGMAR1 (0.33) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4206840 | 0.77 | SIGMAR1 (0.80) | SIGMAR1 | |
| SCHEMBL29802790 | 0.77 | SIGMAR1 (1.00) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1587952 | 0.77 | SIGMAR1 (0.57) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL467191 | 0.77 | SIGMAR1 (1.00) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL2882074 | 0.76 | SIGMAR1 (0.78) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55139381-A | — | — | None | — | — | JP | disclosed |
| US-20110092529-A1 | 1,2,4-Triazole Derivatives and Their Use as Oxytocin Antagonists | PFIZER INC. | 2011-04-21 | — | — | US | disclosed |
| US-6207677-B1 | ADMINISERING SIGMA RECEPTOR BINDING PIPERIDINE DERIVATIVE FOR TREATING ANXIETY, EPILEPSY, CONVULSION, MOVEMENT DISORDER, AMNESIA | H. LUNDBECK A/S (DK) | 2001-03-27 | — | — | US | disclosed |
| US-6090808-A | PSYCHOLOGICAL DISORDERS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 2000-07-18 | — | — | US | disclosed |
| US-6031099-A | Piperidine derivates having anxiolytic effect | H. LUNDBECK A/S (DK) | 2000-02-29 | — | — | US | disclosed |
| EP-0593511-B1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | LUNDBECK & CO AS H (DK) | 1998-09-02 | — | — | EP | disclosed |
| EP-0859004-A1 | Piperidine derivatives having anxiolytic effect | H. LUNDBECK A/S (DK) | 1998-08-19 | — | — | EP | disclosed |
| EP-0649407-B1 | DIMERIC PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | disclosed |
| EP-0853085-A1 | Piperidine derivatives having anxiolytic effect | H. LUNDBECK A/S (DK) | 1998-07-15 | — | — | EP | disclosed |
| US-5665725-A | Piperidine derivatives having anxiolytic effect | Lundbeck, H. (DK) | 1997-09-09 | — | — | US | disclosed |
| US-5658921-A | POTENT SIGMA RECEPTOR LIGANDS; WATER SOLUBILITY; SYMMETRY | H. LUNDBECK A/S (DK) | 1997-08-19 | — | — | US | disclosed |
| EP-0649407-A1 | DIMERIC PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES | H. LUNDBECK A/S (DK) | 1995-04-26 | — | — | EP | disclosed |
| EP-0593511-A1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | H. LUNDBECK A/S (DK) | 1994-04-27 | — | — | EP | disclosed |
| WO-1993025527-A1 | DIMERIC PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES | H. LUNDBECK A/S (DK) | 1993-12-23 | — | — | WO | disclosed |
| WO-1992022554-A1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | H. LUNDBECK A/S (DK) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518805-A1 | Piperidine derivatives | H. LUNDBECK A/S (DK) | 1992-12-16 | — | — | EP | disclosed |
| JP-S55139381-A | SPIROISOCHROMAN | DAI ICHI SEIYAKU CO LTD | 1980-10-31 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092529-A1 | 1,2,4-Triazole Derivatives and Their Use as Oxytocin Antagonists | OXTR, PRLHR, KISS1R | SIGMAR1 748/4885TP53 4827/4885CYP1A2 1180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.