Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29960571 | 0.98 | ITGB2 (0.39) | ITGB2ICAM1ITGALHTR2CHTR2B | |
| SCHEMBL2499601 | 0.90 | HTR2A (0.40) | ITGB2ICAM1ITGALHTR2CHTR2B | |
| SCHEMBL31486441 | 0.87 | ITGB2 (0.48) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL19041436 | 0.87 | ITGB2 (0.48) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL12084777 | 0.84 | ITGB2 (0.41) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL655103 | 0.84 | TNKS (0.41) | HTR2CHTR2BOPRM1SIGMAR1OPRD1 | |
| Hydrochloric Acid SCHEMBL2801131 | 0.82 | TNKS (0.41) | HTR2CHTR2BOPRM1SIGMAR1OPRD1 | |
| SCHEMBL28605146 | 0.81 | ITGB2 (0.43) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL30353245 | 0.79 | ITGB2 (0.44) | ITGB2ICAM1ITGALLMNACRHBP | |
| Hydrochloric Acid SCHEMBL29960592 | 0.79 | HTR2A (0.42) | ITGB2ICAM1ITGALHTR2CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092529-A1 | 1,2,4-Triazole Derivatives and Their Use as Oxytocin Antagonists | PFIZER INC. | 2011-04-21 | — | — | US | disclosed |
| US-20110092529-A1 | 1,2,4-Triazole Derivatives and Their Use as Oxytocin Antagonists | PFIZER INC. | 2011-04-21 | — | — | US | disclosed |
| US-20110092529-A1 | 1,2,4-Triazole Derivatives and Their Use as Oxytocin Antagonists | PFIZER INC. | 2011-04-21 | — | — | US | disclosed |
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | ABBVIE INC. | 2008-07-24 | — | — | US | disclosed |
| WO-2007057775-A1 | SPIROPIPERIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |
| US-6207677-B1 | ADMINISERING SIGMA RECEPTOR BINDING PIPERIDINE DERIVATIVE FOR TREATING ANXIETY, EPILEPSY, CONVULSION, MOVEMENT DISORDER, AMNESIA | H. LUNDBECK A/S (DK) | 2001-03-27 | — | — | US | disclosed |
| US-6090808-A | PSYCHOLOGICAL DISORDERS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 2000-07-18 | — | — | US | disclosed |
| US-6031099-A | Piperidine derivates having anxiolytic effect | H. LUNDBECK A/S (DK) | 2000-02-29 | — | — | US | disclosed |
| US-5837707-A | USEFUL IN TREATING ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSIONS, AMNESIA, PARKINSON'S DISEASE | H. LUNDBECK A/S (DK) | 1998-11-17 | — | — | US | disclosed |
| US-5830896-A | PSYCHOLOGICAL DISORDERS; ANTIEPILEPIC AGENTS; ALZHEIMER'SAND PARKINSON?S DISEASE | H. LUNDBECK A/S (DK) | 1998-11-03 | — | — | US | disclosed |
| US-5807871-A | PSYCHOLOGICAL DISORDERS, ALZHEIMER OR PARKINSON DISEASE | H. LUNDBECK A/S (DK) | 1998-09-15 | — | — | US | disclosed |
| EP-0593511-B1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | LUNDBECK & CO AS H (DK) | 1998-09-02 | — | — | EP | disclosed |
| EP-0649407-B1 | DIMERIC PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | disclosed |
| US-5665725-A | Piperidine derivatives having anxiolytic effect | Lundbeck, H. (DK) | 1997-09-09 | — | — | US | disclosed |
| US-5658921-A | POTENT SIGMA RECEPTOR LIGANDS; WATER SOLUBILITY; SYMMETRY | H. LUNDBECK A/S (DK) | 1997-08-19 | — | — | US | disclosed |
| EP-0593511-A1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | H. LUNDBECK A/S (DK) | 1994-04-27 | — | — | EP | disclosed |
| WO-1992022554-A1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | H. LUNDBECK A/S (DK) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518805-A1 | Piperidine derivatives | H. LUNDBECK A/S (DK) | 1992-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | MIF, CCL5, CCR2 | ITGB2 3551/4885ICAM1 1097/4885ITGAL 2477/4885 |
| US-20110092529-A1 | 1,2,4-Triazole Derivatives and Their Use as Oxytocin Antagonists | OXTR, PRLHR, KISS1R | ITGB2 2920/4885ICAM1 2792/4885ITGAL 3194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.