Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21690488 | 0.84 | MAPT (0.40) | MAPTALDH1A1BLMRECQLF2 | |
| SCHEMBL3281298 | 0.83 | ALDH1A1 (0.56) | MAPTALDH1A1RECQLPKMTSHR | |
| SCHEMBL6306447 | 0.76 | ALDH1A1 (0.50) | MAPTALDH1A1RECQLPKMHSP90AA1 | |
| SCHEMBL140664 | 0.75 | BLM (0.48) | MAPTALDH1A1BLMRECQLF2 | |
| SCHEMBL1282296 | 0.74 | BLM (0.58) | MAPTALDH1A1BLMRECQLF2 | |
| SCHEMBL38341 | 0.74 | BLM (0.58) | MAPTALDH1A1BLMRECQLF2 | |
| SCHEMBL1766180 | 0.74 | BLM (0.58) | MAPTALDH1A1BLMRECQLF2 | |
| SCHEMBL8859053 | 0.74 | CES2 (0.43) | MAPTALDH1A1L3MBTL1HIF1AKMT2A | |
| SCHEMBL2100174 | 0.73 | ALDH1A1 (0.46) | MAPTALDH1A1RECQLPKMTSHR | |
| SCHEMBL2276511 | 0.73 | ALDH1A1 (0.46) | MAPTALDH1A1RECQLPKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694466-B1 | PREPARATION OF SITAGLIPTIN INTERMEDIATES | LEK PHARMACEUTICALS (SI) | 2018-10-24 | — | — | EP | disclosed |
| US-9174930-B2 | Preparation of sitagliptin intermediates | LEK PHARMACEUTICALS D.D. (SI) | 2015-11-03 | — | — | US | disclosed |
| US-20140213810-A1 | PREPARATION OF SITAGLIPTIN INTERMEDIATES | LEK PHARMACEUTICALS D.D. (SI) | 2014-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213810-A1 | PREPARATION OF SITAGLIPTIN INTERMEDIATES | DPP4, DPP3, DPP9 | MAPT 3098/4885ALDH1A1 1546/4885BLM 3471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.