Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MME | P08473 | 4/20 | 0.56 |
| ▸ | ACE | P12821 | 3/20 | 0.56 |
| ▸ | CPA1 | P15085 | 3/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | YAP1 | P46937 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3991020 | 0.88 | YAP1 (0.48) | NPC1RAB9AMMEACECPA1 | |
| SCHEMBL12593593 | 0.85 | YAP1 (0.59) | ACELMNAYAP1ALDH1A1HSD17B10 | |
| SCHEMBL7939814 | 0.84 | NPC1 (0.53) | NPC1RAB9AMMEACECPA1 | |
| SCHEMBL7942074 | 0.82 | NPC1 (0.51) | NPC1RAB9AMMEACECPA1 | |
| SCHEMBL21358718 | 0.80 | RAB9A (0.64) | NPC1RAB9AEPHX2POLB | |
| SCHEMBL21358716 | 0.80 | RAB9A (0.64) | NPC1RAB9AEPHX2POLB | |
| SCHEMBL2881350 | 0.80 | LTA4H (0.61) | ACEACE2LTA4H | |
| SCHEMBL2881349 | 0.80 | LTA4H (0.61) | ACEACE2LTA4H | |
| SCHEMBL5612699 | 0.79 | LMNA (0.73) | MMEACECPA1ACE2LMNA | |
| SCHEMBL10665563 | 0.79 | LMNA (0.73) | MMEACECPA1ACE2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791264-B2 | Benzenesulfonamide compounds and their use as blockers of calcium channels | PURDUE PHARMA L.P. (US) | 2014-07-29 | — | — | US | disclosed |