Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trifluoperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.83 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.83 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.83 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.83 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.72 |
| ▸ | RAD52 | P43351 | 3/20 | 0.84 |
| ▸ | FPR2 | P25090 | 12/20 | 0.83 |
| ▸ | LMNA | P02545 | 7/20 | 0.83 |
| ▸ | MAPT | P10636 | 7/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.83 |
| ▸ | TP53 | P04637 | 3/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.83 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.83 |
| ▸ | HTR1A | P08908 | 2/20 | 0.83 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.83 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoperazine SCHEMBL1590789 | 1.00 | RAD52 (0.84) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL27892292 | 0.93 | RAD52 (0.89) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Fluphenazine SCHEMBL565707 | 0.93 | LMNA (0.85) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Fluphenazine SCHEMBL565708 | 0.93 | LMNA (0.85) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL24866 | 0.91 | FPR2 (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL29603012 | 0.91 | FPR2 (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL1897003 | 0.91 | FPR2 (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Acetophenazine SCHEMBL2448563 | 0.90 | LMNA (0.71) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL23039392 | 0.90 | LMNA (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL29579627 | 0.90 | LMNA (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-20240016745-A1 | TIMED-ELUTION MASKING PARTICLES AND ORAL PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | TOWA PHARMACEUTICAL CO., LTD. (JP) | 2024-01-18 | — | — | US | disclosed |
| EP-4260847-A1 | TIMED-ELUTION MASKING PARTICLES AND ORAL PHARMACEUTICAL COMPOSITION CONTAINING SAME | TOWA PHARMACEUTICAL CO., LTD. (JP) | 2023-10-18 | — | — | EP | disclosed |
| EP-2465539-B1 | DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET | FUJI CHEM IND CO LTD (JP) | 2018-07-11 | — | — | EP | disclosed |
| US-9579312-B2 | Method for treating/preventing disease using cognitive ability of cerebrum and pharmaceutical | SYSTEM C (JP) | 2017-02-28 | — | — | US | disclosed |
| EP-2465540-B1 | DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET | FUJI CHEM IND CO LTD (JP) | 2016-10-05 | — | — | EP | disclosed |
| US-9446055-B2 | Disintegrating particle composition and orally rapidly disintegrating tablet | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2016-09-20 | — | — | US | disclosed |
| US-20150320735-A1 | METHOD FOR TREATING/PREVENTING DISEASE USING COGNITIVE ABILITY OF CEREBRUM AND PHARMACEUTICAL | SYSTEM C (JP) | 2015-11-12 | — | — | US | disclosed |
| US-8900602-B2 | Disintegrating particle composition and orally rapidly disintegrating tablet | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2014-12-02 | — | — | US | disclosed |
| EP-2700401-A1 | METHOD FOR PRODUCING ADHESIVE PATCH, AND ADHESIVE PATCH | Hisamitsu Pharmaceutical Co., Inc. (JP) | 2014-02-26 | — | — | EP | disclosed |
| CN-103338789-A | Pharmaceutical composition containing poorly water-soluble drug | KOWA CO | 2013-10-02 | — | — | CN | disclosed |
| US-20120165413-A1 | DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-06-28 | — | — | US | disclosed |
| US-20120156261-A1 | DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-06-21 | — | — | US | disclosed |
| EP-2465539-A1 | DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-06-20 | — | — | EP | disclosed |
| EP-2465540-A1 | DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-06-20 | — | — | EP | disclosed |
| US-20110092548-A1 | METHOD FOR TREATING/PREVENTING DISEASE USING COGNITIVE ABILITY OF CEREBRUM AND PHARMACEUTICAL | MINOWADA TAKURO | 2011-04-21 | — | — | US | disclosed |
| EP-2005956-A1 | METHOD FOR TREATING/PREVENTING DISEASE USING COGNITIVE ABILITY OF CEREBRUM AND PHARMACEUTICAL | Minowada, Takuro (JP) | 2008-12-24 | — | — | EP | disclosed |
| EP-0665009-B1 | CRYSTALLINE CONDITION DISLOCATING METHOD | NIPPON SHINYAKU CO LTD (JP) | 2000-02-16 | — | — | EP | disclosed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0665009-A1 | CRYSTALLINE CONDITION DISLOCATING METHOD | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1995-08-02 | — | — | EP | disclosed |