Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15908539 | 0.91 | SPHK1 (0.35) | SPHK1PIK3CDPIK3CAPIK3CBMTOR | |
| SCHEMBL15908553 | 0.91 | GRIN2B (0.37) | SPHK1GRIN2B | |
| SCHEMBL15908537 | 0.89 | SPHK1 (0.34) | SPHK1PIK3CDMTORGRIN2B | |
| SCHEMBL15908533 | 0.85 | CNR2 (0.33) | — | |
| SCHEMBL15908554 | 0.85 | CYP1A2 (0.34) | GRIN2B | |
| SCHEMBL15908562 | 0.85 | TSHR (0.36) | — | |
| SCHEMBL15908559 | 0.81 | CNR2 (0.36) | — | |
| SCHEMBL15908534 | 0.79 | HSP90AA1 (0.38) | SPHK1PIK3CA | |
| SCHEMBL15554095 | 0.74 | CYP3A4 (0.34) | — | |
| SCHEMBL16653073 | 0.71 | CYP3A4 (0.33) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190023692-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2019-01-24 | — | — | US | disclosed |
| US-20170260166-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2017-09-14 | — | — | US | disclosed |
| US-20170260166-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2017-09-14 | — | — | US | disclosed |
| EP-2948444-B1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-12-07 | — | — | EP | disclosed |
| WO-2014114776-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2014-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190023692-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | SQOR, SDHA, DHX15 | PDE5A 2542/4885AAK1 3163/4885SPHK1 773/4885 |
| US-20170260166-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS | ATIC, DHX15, SQOR | PDE5A 2404/4885AAK1 1665/4885SPHK1 635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.