Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | MAX | P61244 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15909005 | 0.91 | HDAC1 (0.40) | P2RX7POLBLMNANPC1RAB9A | |
| SCHEMBL15909074 | 0.90 | NPC1 (0.39) | P2RX7POLBLMNANPC1RAB9A | |
| SCHEMBL15909062 | 0.89 | NPC1 (0.38) | P2RX7POLBLMNANPC1RAB9A | |
| SCHEMBL1614902 | 0.85 | HPGD (0.35) | POLBLMNAKDM4EMYCMAX | |
| SCHEMBL1614735 | 0.84 | PLAT (0.33) | NPC1RAB9AKDM4EMYCMAX | |
| SCHEMBL1615018 | 0.81 | HCAR2 (0.35) | POLBLMNANPC1RAB9AKDM4E | |
| SCHEMBL1278731 | 0.79 | PDE2A (0.44) | P2RX7POLBLMNATRPV1BACE1 | |
| SCHEMBL15926359 | 0.79 | KDM4E (0.35) | POLBLMNARAB9AKDM4EMYC | |
| SCHEMBL15909598 | 0.75 | LMNA (0.43) | P2RX7POLBLMNATRPV1SMN1; SMN2 | |
| SCHEMBL15926318 | 0.75 | MAPK14 (0.32) | KDM4EMYCMAX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |