Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1278731 | 0.87 | PDE2A (0.44) | LMNAPOLBPDE2ADGAT2BACE1 | |
| SCHEMBL15926264 | 0.85 | LMNA (0.37) | LMNAPDE2AKCNQ3KCNQ2 | |
| SCHEMBL15926314 | 0.85 | KCNQ3 (0.36) | LMNAPOLBPDE2AHDAC6TRPV1 | |
| SCHEMBL15909005 | 0.83 | HDAC1 (0.40) | LMNAPOLBPDE2ABACE1BACE2 | |
| SCHEMBL1278758 | 0.79 | KCNQ3 (0.49) | KCNQ3KCNQ2 | |
| SCHEMBL15909062 | 0.77 | NPC1 (0.38) | LMNAPOLBBACE1TRPV1P2RX7 | |
| SCHEMBL1614661 | 0.77 | LMNA (0.36) | LMNAPOLBKCNQ3KCNQ2SMN1; SMN2 | |
| SCHEMBL1614928 | 0.76 | KCNQ3 (0.36) | LMNAPOLBPDE2APTGESTRPV1 | |
| SCHEMBL15909074 | 0.75 | NPC1 (0.39) | LMNAPOLBBACE1TRPV1P2RX7 | |
| SCHEMBL15909002 | 0.75 | P2RX7 (0.40) | LMNAPOLBBACE1TRPV1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |