Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15909062 | 0.94 | NPC1 (0.38) | HDAC1NPC1RAB9ALMNAPOLB | |
| SCHEMBL15909074 | 0.91 | NPC1 (0.39) | HDAC1NPC1RAB9ALMNAPOLB | |
| SCHEMBL15909002 | 0.91 | P2RX7 (0.40) | HDAC1NPC1RAB9ALMNAPOLB | |
| SCHEMBL15926359 | 0.89 | KDM4E (0.35) | RAB9ALMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL1278731 | 0.87 | PDE2A (0.44) | LMNAPOLBTRPV1BACE1P2RX7 | |
| SCHEMBL15926318 | 0.84 | MAPK14 (0.32) | KDM4EALDH1A1GAA | |
| SCHEMBL15909598 | 0.83 | LMNA (0.43) | LMNAPOLBTRPV1BACE1P2RX7 | |
| SCHEMBL15926361 | 0.81 | HCAR2 (0.35) | NPC1RAB9AKDM4EKMT2AALDH1A1 | |
| SCHEMBL15926328 | 0.79 | MAPK14 (0.31) | — | |
| SCHEMBL15908944 | 0.78 | HTT (0.39) | NPC1RAB9ALMNAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |