Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 5/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923693 | 0.83 | RORC (0.41) | KDM4EALDH1A1RORCNPC1RAB9A | |
| SCHEMBL19330053 | 0.79 | MMP12 (0.38) | KDM4EALDH1A1RPS6KA3TLR8ADORA2A | |
| SCHEMBL23332542 | 0.78 | RORC (0.47) | RORC | |
| SCHEMBL12362503 | 0.75 | KDM4E (0.38) | KDM4EALDH1A1PPARG | |
| SCHEMBL12362489 | 0.72 | TLR7 (0.35) | PIK3CA | |
| SCHEMBL9847092 | 0.72 | TLR8 (0.48) | TLR8NPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL15071631 | 0.70 | KDM4E (0.43) | KDM4EALDH1A1TLR8RORCNPC1 | |
| SCHEMBL8291795 | 0.69 | GPR4 (0.43) | — | |
| SCHEMBL23459658 | 0.68 | RPS6KA3 (0.38) | KDM4EALDH1A1RPS6KA3GAARAB9A | |
| SCHEMBL24402003 | 0.68 | DPP4 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762476-A1 | 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE | Taiho Pharmaceutical Co., Ltd. (JP) | 2014-08-06 | — | — | EP | disclosed |