Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CLPP | Q16740 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | FPR3 | P25089 | 1/20 | 0.30 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10228036 | 0.82 | KDM4E (0.47) | KDM1AKDM1BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL16922694 | 0.81 | KDM1A (0.39) | KDM1AKCNH2KDM1BCYP1A2CYP2D6 | |
| SCHEMBL12533678 | 0.79 | KDM1A (0.38) | KDM1AKCNH2KDM1BCYP1A2CYP2D6 | |
| SCHEMBL377446 | 0.79 | CYP1A2 (0.41) | KDM1AKCNH2KDM1BCYP1A2CYP2D6 | |
| SCHEMBL1503157 | 0.78 | HTT (0.45) | KDM1ATTR | |
| SCHEMBL29489387 | 0.78 | HTT (0.45) | KDM1ATTR | |
| SCHEMBL11019831 | 0.78 | PTPRC (0.34) | KDM4ETSHRCA1CA2TTR | |
| SCHEMBL15352097 | 0.77 | KDM1A (0.37) | KDM1AKCNH2KDM1BCYP1A2CYP2D6 | |
| SCHEMBL8079708 | 0.77 | KDM1A (0.37) | KDM1AKCNH2KDM1BCYP1A2CYP2D6 | |
| SCHEMBL855443 | 0.77 | LOXL2 (0.46) | KDM1AKCNH2KDM1BRCOR1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154970-B1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME (US) | 2019-11-06 | — | — | EP | disclosed |
| EP-3154970-B1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME (US) | 2019-11-06 | — | — | EP | disclosed |
| CN-106661018-B | Pyrrolo- [2,3-C] pyridine as neurofibrillary tangles imaging agent | 默沙东公司 | 2019-07-19 | — | — | CN | disclosed |
| US-10231953-B2 | Inhibitors of bromodomains | ZENITH EPIGENETICS LTD. (CA) | 2019-03-19 | — | — | US | disclosed |
| US-10022461-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles | MERCK SHARP & DOHME CORP. (US) | 2018-07-17 | — | — | US | disclosed |
| US-10022461-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles | MERCK SHARP & DOHME CORP. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20180071412-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2018-03-15 | — | — | US | disclosed |
| US-20180071412-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2018-03-15 | — | — | US | disclosed |
| US-20170360760-A1 | Inhibitors of Bromodomains | ZENITH EPIGENETICS CORP. (CA) | 2017-12-21 | — | — | US | disclosed |
| US-20170360760-A1 | Inhibitors of Bromodomains | ZENITH EPIGENETICS CORP. (CA) | 2017-12-21 | — | — | US | disclosed |
| CN-106661018-A | Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles | 默沙东公司 | 2017-05-10 | — | — | CN | disclosed |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | US | disclosed |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | US | disclosed |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | US | disclosed |
| EP-3154970-A2 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | Merck Sharp & Dohme Corp. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2016097863-A1 | INHIBITORS OF BROMODOMAINS | ZENITH EPIGENETICS CORP. (CA) | 2016-06-23 | — | — | WO | disclosed |
| WO-2015191506-A2 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2015-12-17 | — | — | WO | disclosed |
| WO-2015191506-A2 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2015-12-17 | — | — | WO | disclosed |
| US-20140213538-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. | 2014-07-31 | — | — | US | disclosed |
| US-20140213538-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. | 2014-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213538-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR5 | KDM1A 3743/4885KCNH2 1624/4885KDM1B 3605/4885 |
| US-20170360760-A1 | Inhibitors of Bromodomains | BRDT, BRD3, BRPF3 | KDM1A 348/4885KCNH2 4589/4885KDM1B 199/4885 |
| US-10231953-B2 | Inhibitors of bromodomains | BRDT, BRD3, BRPF3 | KDM1A 348/4885KCNH2 4589/4885KDM1B 199/4885 |
| US-10022461-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles | MAPT, SNCA, PARK7 | KDM1A 4217/4885KCNH2 1247/4885KDM1B 4246/4885 |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MAPT, SNCA, PARK7 | KDM1A 4084/4885KCNH2 1488/4885KDM1B 4097/4885 |
| US-20180071412-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MAPT, SNCA, PARK7 | KDM1A 4217/4885KCNH2 1247/4885KDM1B 4246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.