SCHEMBL377446

SCHEMBL377446

Fc1cc(CBr)ccc1Br

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
KDM1A O60341 3/20 0.38
KCNH2 Q12809 2/20 0.38
KDM1B Q8NB78 1/20 0.38
HTT P42858 2/20 0.37
PTPRB P23467 1/20 0.35
MEP1B Q16820 2/20 0.35
ALDH1A1 P00352 2/20 0.35
TRPA1 O75762 1/20 0.35
TSHR P16473 1/20 0.35
RCOR1 Q9UKL0 1/20 0.34
KDM4E B2RXH2 1/20 0.33
KIF11 P52732 1/20 0.33
PYCR1 P32322 1/20 0.32
PARP1 P09874 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16922694 0.83 KDM1A (0.39) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL29410058 0.82 TDP1 (0.39) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL2298160 0.82 TDP1 (0.39) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL333551 0.81 CYP1A2 (0.53) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL12533678 0.81 KDM1A (0.38) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL29418197 0.81 CYP1A2 (0.53) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL118519 0.80 HTT (0.47) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL29410646 0.80 HTT (0.47) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL8079708 0.79 KDM1A (0.37) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL15912481 0.79 KDM1A (0.37) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 419 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113956160-A Preparation method of flurbiprofen impurity F 北京茗泽中和药物研究有限公司 2022-01-21 CN claimed
EP-4731262-A1 PHARMACEUTICAL COMPOSITION COMPRISING A QUINAZOLINE COMPOUND Astellas Pharma Inc. (JP) 2026-04-29 EP disclosed
US-12612360-B2 Substituted 6,7-dihydro-5H-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof SANOFI (FR) 2026-04-28 US disclosed
EP-4704839-A2 IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF ALPHERABIO LLC (US) 2026-03-11 EP disclosed
US-20260062420-A1 NOVEL DPP1 INHIBITORS AND USES THEREOF INSMED INC (US) 2026-03-05 US disclosed
US-12479816-B2 20-HETE formation inhibitors University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2025-11-25 US disclosed
US-20250353829-A1 BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF TEMPEST THERAPEUTICS INC (US) 2025-11-20 US disclosed
US-20250333429-A1 MODULATORS OF TNF-ALPHA ACTIVITY FORWARD THERAPEUTICS INC (US) 2025-10-30 US disclosed
EP-4622981-A1 MODULATORS OF TNF-ALPHA ACTIVITY Forward Therapeutics, Inc. (US) 2025-10-01 EP disclosed
EP-4622716-A1 SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS Treeline Biosciences, Inc. (US) 2025-10-01 EP disclosed
EP-0640595-B1 SUBSTITUTED TERTIARY AMINO COMPOUND OR SALT THEREOF YAMANOUCHI PHARMA CO LTD (JP) 1999-03-24 EP disclosed
CN-1039228-C Novel substituted tert-amino compund YAMANOUCHI PHARMA CO LTD (JP) 1998-07-22 CN disclosed
US-5538976-A ANTICARCINOGENIC AGENTS AND ENZYME INHIBITORS FOR AROMATASE YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1996-07-23 US disclosed
EP-0346107-B1 Arylfluoroalkenamides and their use as pesticides ROUSSEL UCLAF (FR) 1995-09-13 EP disclosed
US-5411980-A Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists MERCK & CO., INC. (US) 1995-05-02 US disclosed
EP-0640595-A1 NOVEL SUBSTITUTED TERTIARY AMINO COMPOUND OR SALT THEREOF YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1995-03-01 EP disclosed
US-5281614-A Hypotensive agents, glaucoma or angiotensin antagonists MERCK & CO., INC. (US) 1994-01-25 US disclosed
CN-1079962-A New substituted tertiary amine compound and salt thereof YAMANOUCHI PHARMA CO LTD (JP) 1993-12-29 CN disclosed
US-5180737-A Insecticides, nematocides or anthelmintics ROUSSEL UCLAF (FR) 1993-01-19 US disclosed
EP-0346107-A2 Arylfluoroalkenamides and their use as pesticides ROUSSEL UCLAF (FR) 1989-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12612360-B2 Substituted 6,7-dihydro-5H-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof ESRRA, FSHR, GPER1 CYP1A2 577/4885CYP2D6 518/4885CYP2C9 1149/4885
US-12479816-B2 20-HETE formation inhibitors CYP4A22, ALOX5, ALOX15 CYP1A2 41/4885CYP2D6 97/4885CYP2C9 84/4885
US-20250353829-A1 BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF PTGER4, PTGER2, CNR2 CYP1A2 682/4885CYP2D6 1748/4885CYP2C9 1761/4885
US-20260062420-A1 NOVEL DPP1 INHIBITORS AND USES THEREOF DPP4, DPP3, DPP7 CYP1A2 2410/4885CYP2D6 512/4885CYP2C9 1938/4885
US-20250333429-A1 MODULATORS OF TNF-ALPHA ACTIVITY TNF, NFKBIA, TNFRSF1A CYP1A2 3971/4885CYP2D6 4577/4885CYP2C9 4750/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.