Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.54 |
| ▸ | CCR5 | P51681 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.46 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367447 | 0.88 | PTGDR2 (0.60) | ALOX5APCCR5LMNASLC6A4RXRA | |
| SCHEMBL4642584 | 0.83 | ALOX5AP (0.55) | ALOX5APLMNAMRGPRX4RXRARXRB | |
| SCHEMBL19404699 | 0.81 | ALOX5AP (0.61) | ALOX5APMRGPRX4RXRARXRBRXRG | |
| SCHEMBL6530691 | 0.80 | PTGDR2 (0.56) | CCR5LMNASLC6A4RXRARXRB | |
| SCHEMBL31644088 | 0.80 | SLC6A4 (0.66) | CCR5LMNASLC6A4ALDH1A1RAB9A | |
| SCHEMBL9446223 | 0.80 | RXRA (0.71) | ALOX5APMRGPRX4RXRARXRBRXRG | |
| SCHEMBL368071 | 0.80 | SLC6A4 (0.66) | CCR5LMNASLC6A4ALDH1A1RAB9A | |
| SCHEMBL18587641 | 0.79 | ALOX5AP (0.46) | ALOX5APCCR5LMNAMRGPRX4RXRA | |
| SCHEMBL15197125 | 0.79 | CCR5 (0.54) | CCR5LMNASLC6A4RXRARXRB | |
| SCHEMBL1584529 | 0.79 | SLC6A4 (0.54) | CCR5SLC6A4ALDH1A1RAB9AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951169-B1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-08-28 | — | — | EP | disclosed |
| US-9926333-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-27 | — | — | US | disclosed |
| US-20170327514-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-16 | — | — | US | disclosed |
| US-9732093-B2 | FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-15 | — | — | US | disclosed |
| US-20150368270-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-24 | — | — | US | disclosed |
| US-20150252008-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-10 | — | — | US | disclosed |
| US-9073876-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-07 | — | — | US | disclosed |
| US-20140221310-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (US) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327514-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | ALOX5AP 70/4885CCR5 394/4885LMNA 3996/4885 |
| US-20140221310-A1 | FLAP MODULATORS | FEN1, PGF, PTGIS | ALOX5AP 61/4885CCR5 370/4885LMNA 4150/4885 |
| US-20150368270-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | ALOX5AP 70/4885CCR5 394/4885LMNA 3996/4885 |
| US-20150252008-A1 | FLAP MODULATORS | FEN1, PGF, PTGIS | ALOX5AP 61/4885CCR5 370/4885LMNA 4150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.