Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 17/20 | 0.61 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591016 | 1.00 | GRIA2 (0.61) | GRIA2AADATDGAT1 | |
| SCHEMBL1591019 | 1.00 | GRIA2 (0.61) | GRIA2AADATDGAT1 | |
| SCHEMBL1591094 | 0.81 | GRIA2 (0.73) | GRIA2 | |
| SCHEMBL1590735 | 0.80 | GRIA2 (0.68) | GRIA2AADAT | |
| SCHEMBL1423237 | 0.80 | GRIA2 (0.68) | GRIA2AADAT | |
| SCHEMBL7961698 | 0.80 | GRIA2 (0.71) | GRIA2 | |
| SCHEMBL1422644 | 0.80 | GRIA2 (0.68) | GRIA2AADAT | |
| SCHEMBL7966871 | 0.80 | GRIA2 (0.63) | GRIA2 | |
| SCHEMBL1592052 | 0.77 | CTSD (0.42) | — | |
| SCHEMBL1590874 | 0.77 | CTSD (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297110-B1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | MERCK SHARP & DOHME (NL) | 2015-05-20 | — | — | EP | disclosed |
| US-8536214-B2 | Indane derivatives as AMPA receptor modulators | N.V. ORGANON (NL) | 2013-09-17 | — | — | US | disclosed |
| US-20110092539-A1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | N.V. ORGANON (NL) | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092539-A1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | GRIK5, GRIN3A, GRIK2 | GRIA2 27/4885AADAT 327/4885DGAT1 3268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.