Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 3/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1590872 | 1.00 | CTSD (0.42) | CTSDGRIN2BNAMPTDRD2DRD3 | |
| SCHEMBL1590874 | 1.00 | CTSD (0.42) | CTSDGRIN2BNAMPTDRD2DRD3 | |
| SCHEMBL1591952 | 0.83 | CTSD (0.42) | CTSDAGERMTNR1ACHRM2CHRM3 | |
| SCHEMBL1591950 | 0.83 | CTSD (0.42) | CTSDAGERMTNR1ACHRM2CHRM3 | |
| SCHEMBL1591433 | 0.77 | GRIA2 (0.61) | — | |
| SCHEMBL1591019 | 0.77 | GRIA2 (0.61) | — | |
| SCHEMBL1591016 | 0.77 | GRIA2 (0.61) | — | |
| SCHEMBL17352482 | 0.76 | CTSD (0.50) | CTSDAGERMTNR1ACHRM2CHRM3 | |
| SCHEMBL6134728 | 0.75 | DRD2 (0.58) | GRIN2BDRD2DRD3 | |
| SCHEMBL6134727 | 0.75 | DRD2 (0.58) | GRIN2BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297110-B1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | MERCK SHARP & DOHME (NL) | 2015-05-20 | — | — | EP | disclosed |
| US-8536214-B2 | Indane derivatives as AMPA receptor modulators | N.V. ORGANON (NL) | 2013-09-17 | — | — | US | disclosed |
| US-20110092539-A1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | N.V. ORGANON (NL) | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092539-A1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | GRIK5, GRIN3A, GRIK2 | CTSD 4681/4885GRIN2B 10/4885NAMPT 2732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.