SCHEMBL15915212

SCHEMBL15915212

O=C(CS(=O)(=O)c1ccccc1Br)N1CCOCC1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.52
POLB P06746 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
ALDH1A1 P00352 5/20 0.51
TP53 P04637 1/20 0.51
LMNA P02545 1/20 0.48
FKBP1A P62942 2/20 0.47
PLCG1 P19174 1/20 0.46
MAPT P10636 1/20 0.45
NPC1 O15118 1/20 0.45
GAA P10253 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1927046 0.74 KMT2A (0.44) RAB9APOLBSMN1; SMN2ALDH1A1TP53
SCHEMBL6227110 0.74 RAB9A (0.57) RAB9ASMN1; SMN2ALDH1A1FKBP1AMAPT
SCHEMBL22501227 0.72 MAPT (0.51) RAB9APOLBSMN1; SMN2ALDH1A1FKBP1A
SCHEMBL20627051 0.71 POLB (0.53) POLBSMN1; SMN2L3MBTL1ALDH1A1LMNA
SCHEMBL11226379 0.71 PLCG1 (0.60) POLBL3MBTL1ALDH1A1PLCG1MAPT
SCHEMBL15916219 0.70 POLB (0.69) RAB9APOLBSMN1; SMN2ALDH1A1TP53
SCHEMBL20626954 0.69 RAB9A (0.51) RAB9APOLBSMN1; SMN2L3MBTL1ALDH1A1
SCHEMBL31661720 0.68 ALDH1A1 (0.67) RAB9ASMN1; SMN2L3MBTL1ALDH1A1TP53
SCHEMBL1663182 0.68 ALDH1A1 (0.67) RAB9ASMN1; SMN2L3MBTL1ALDH1A1TP53
SCHEMBL28911450 0.68 PLCG1 (0.56) RAB9APOLBSMN1; SMN2ALDH1A1PLCG1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3495359-A1 FLAP MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed
EP-3495359-A1 FLAP MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed
EP-3070085-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2019-01-09 EP disclosed
EP-3070085-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2019-01-09 EP disclosed
EP-2951170-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-10-24 EP disclosed
US-9884878-B2 FLAP modulators JANSSEN PHARMACEUTICA NV (BE) 2018-02-06 US disclosed
US-9884878-B2 FLAP modulators JANSSEN PHARMACEUTICA NV (BE) 2018-02-06 US disclosed
US-9884878-B2 FLAP modulators JANSSEN PHARMACEUTICA NV (BE) 2018-02-06 US disclosed
US-9745328-B2 Flap modulators JANSSEN PHARMACEUTICA NV (BE) 2017-08-29 US disclosed
US-9745328-B2 Flap modulators JANSSEN PHARMACEUTICA NV (BE) 2017-08-29 US disclosed
US-20150259357-A1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-09-17 US disclosed
US-20150259357-A1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-09-17 US disclosed
US-9079866-B2 Flap modulators JANSSEN PHARMACEUTICA NV (BE) 2015-07-14 US disclosed
US-9079866-B2 Flap modulators JANSSEN PHARMACEUTICA NV (BE) 2015-07-14 US disclosed
US-9079866-B2 Flap modulators JANSSEN PHARMACEUTICA NV (BE) 2015-07-14 US disclosed
US-20140221311-A1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (US) 2014-08-07 US disclosed
US-20140221311-A1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (US) 2014-08-07 US disclosed
WO-2014121055-A2 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-08-07 WO disclosed
US-20140221311-A1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (US) 2014-08-07 US disclosed
WO-2014121055-A2 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-08-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150259357-A1 FLAP MODULATORS PGF, FEN1, TBXA2R RAB9A 2559/4885POLB 1233/4885SMN1; SMN2 3231/4885
US-20140221311-A1 FLAP MODULATORS PGF, FEN1, TBXA2R RAB9A 2559/4885POLB 1233/4885SMN1; SMN2 3231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.