Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15917572 | 0.90 | CASP1 (0.44) | CASP1SMN1; SMN2GAAHTTALDH1A1 | |
| SCHEMBL15918420 | 0.89 | CASP1 (0.46) | CASP1SMN1; SMN2GAAALDH1A1CYP3A4 | |
| SCHEMBL15918247 | 0.89 | CASP1 (0.40) | CASP1SMN1; SMN2ALDH1A1CYP3A4MAPT | |
| SCHEMBL15916968 | 0.89 | MEN1 (0.44) | CASP1SMN1; SMN2GAAHTTALDH1A1 | |
| SCHEMBL15918058 | 0.89 | MAPT (0.44) | CASP1SMN1; SMN2GAAALDH1A1CYP3A4 | |
| SCHEMBL4013821 | 0.88 | ALDH1A1 (0.53) | CASP1SMN1; SMN2GAAALDH1A1CYP3A4 | |
| SCHEMBL15918203 | 0.87 | ALOX15 (0.41) | CASP1SMN1; SMN2MAPTRAB9AKMT2A | |
| SCHEMBL15918366 | 0.86 | NPSR1 (0.46) | CASP1GAAALDH1A1MAPTPOLB | |
| SCHEMBL28179798 | 0.86 | CASP1 (0.39) | CASP1SMN1; SMN2ALDH1A1CYP3A4MAPT | |
| SCHEMBL17221835 | 0.85 | ALDH1A1 (0.41) | ALDH1A1CYP3A4MAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220251039-A1 | Diaryl-B-Lactam Compound and Preparation Method and Pharmaceutical Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2022-08-11 | — | — | US | disclosed |
| EP-3438105-B1 | DIARYL- -LACTAM COMPOUND AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | UNIV FUDAN (CN) | 2022-01-05 | — | — | EP | disclosed |
| EP-3438105-B1 | DIARYL- -LACTAM COMPOUND AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | UNIV FUDAN (CN) | 2022-01-05 | — | — | EP | disclosed |
| US-20200392150-A1 | Diaryl-B-Lactam Compound and Preparation Method and Pharmaceutical Use Thereof | FUDAN UNIVERSITY (CN) | 2020-12-17 | — | — | US | disclosed |
| US-20200392150-A1 | Diaryl-B-Lactam Compound and Preparation Method and Pharmaceutical Use Thereof | FUDAN UNIVERSITY (CN) | 2020-12-17 | — | — | US | disclosed |
| EP-3438105-A1 | DIARYL- -LACTAM COMPOUND AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | Fudan University (CN) | 2019-02-06 | — | — | EP | disclosed |
| EP-3438105-A1 | DIARYL- -LACTAM COMPOUND AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | Fudan University (CN) | 2019-02-06 | — | — | EP | disclosed |
| WO-2017167183-A1 | DIARYL-Β-LACTAM COMPOUND AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 复旦大学 | 2017-10-05 | — | — | WO | disclosed |
| US-9562045-B2 | Process for preparation of indolizine based derivatives as potential phosphodiestrase 3 (PDE3) inhibitors | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-02-07 | — | — | US | disclosed |
| US-9518014-B2 | Process for synthesis of ezetimibe and intermediates used in said process | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2016-12-13 | — | — | US | disclosed |
| US-9505760-B2 | Pyridopyrimidine based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-11-29 | — | — | US | disclosed |
| US-20160194319-A1 | PYRIDOPYRIMIDINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2016-07-07 | — | — | US | disclosed |
| US-20160159792-A1 | PROCESS FOR PREPARATION OF INDOLIZINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTRASE 3 (PDE3) INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-06-09 | — | — | US | disclosed |
| US-9249139-B2 | Indolizinone based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-02-02 | — | — | US | disclosed |
| US-9242982-B2 | Pyridopyrimidine based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-01-26 | — | — | US | disclosed |
| US-20150166479-A1 | PROCESS FOR SYNTHESIS OF EZETIMIBE AND INTERMEDIATES USED IN SAID PROCESS | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2015-06-18 | — | — | US | disclosed |
| US-20140296530-A1 | INDOLIZINONE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-10-02 | — | — | US | disclosed |
| US-20140221651-A1 | PYRIDOPYRIMIDINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166479-A1 | PROCESS FOR SYNTHESIS OF EZETIMIBE AND INTERMEDIATES USED IN SAID PROCESS | HMGCR, COASY, APOB | CASP1 4282/4885SMN1; SMN2 2297/4885GAA 319/4885 |
| US-20140296530-A1 | INDOLIZINONE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | PDE3A, PDE3B, PDE5A | CASP1 2411/4885SMN1; SMN2 2223/4885GAA 1044/4885 |
| US-20140221651-A1 | PYRIDOPYRIMIDINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | PDE3A, PDE3B, PDE5A | CASP1 1428/4885SMN1; SMN2 2679/4885GAA 571/4885 |
| US-20200392150-A1 | Diaryl-B-Lactam Compound and Preparation Method and Pharmaceutical Use Thereof | PEPD, SQLE, BACE1 | CASP1 229/4885SMN1; SMN2 3127/4885GAA 132/4885 |
| US-20160194319-A1 | PYRIDOPYRIMIDINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | PDE3A, PDE3B, PDE5A | CASP1 1699/4885SMN1; SMN2 2882/4885GAA 1007/4885 |
| US-20220251039-A1 | Diaryl-B-Lactam Compound and Preparation Method and Pharmaceutical Use Thereof | PEPD, SQLE, BACE1 | CASP1 229/4885SMN1; SMN2 3127/4885GAA 132/4885 |
| US-20160159792-A1 | PROCESS FOR PREPARATION OF INDOLIZINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTRASE 3 (PDE3) INHIBITORS | PDE3A, PDE5A, PDE3B | CASP1 1741/4885SMN1; SMN2 2125/4885GAA 1039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.