Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 8/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MITF | O75030 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15919336 | 0.85 | ALDH1A1 (0.76) | NOTUMSMN1; SMN2HPGDRAB9AHTT | |
| SCHEMBL15919335 | 0.85 | NOTUM (0.71) | NOTUMSMN1; SMN2HPGDRAB9APOLB | |
| SCHEMBL5820722 | 0.84 | NOTUM (0.67) | NOTUMSMN1; SMN2HPGDRAB9APOLB | |
| SCHEMBL5820723 | 0.84 | NOTUM (0.67) | NOTUMSMN1; SMN2HPGDRAB9APOLB | |
| SCHEMBL15919337 | 0.83 | ALDH1A1 (0.61) | NOTUMSMN1; SMN2HPGDRAB9APOLB | |
| SCHEMBL26220812 | 0.83 | NOTUM (0.65) | NOTUMSMN1; SMN2HPGDRAB9APOLB | |
| SCHEMBL10372395 | 0.80 | NOTUM (0.75) | NOTUMSMN1; SMN2HPGDRAB9APOLB | |
| SCHEMBL20604296 | 0.80 | NOTUM (1.00) | NOTUMSMN1; SMN2HPGDRAB9AHTT | |
| SCHEMBL6922583 | 0.79 | SMN1; SMN2 (0.97) | NOTUMSMN1; SMN2HPGDRAB9APOLB | |
| SCHEMBL19501341 | 0.79 | NOTUM (0.58) | NOTUMSMN1; SMN2HPGDRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014116228-A1 | USP14 INHIBITORS FOR TREATING OR PREVENTING VIRAL INFECTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-07-31 | — | — | WO | disclosed |