Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.61 |
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | HTT | P42858 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 7/20 | 0.49 |
| ▸ | MITF | O75030 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15919341 | 0.83 | NOTUM (0.67) | ALDH1A1MAPTHTTSMN1; SMN2CYP2C19 | |
| SCHEMBL31598889 | 0.83 | ALDH1A1 (0.61) | ALDH1A1MAPTHTTSMN1; SMN2CYP2C19 | |
| SCHEMBL6921673 | 0.82 | SMN1; SMN2 (0.72) | ALDH1A1MAPTHTTSMN1; SMN2CYP2C19 | |
| SCHEMBL17949839 | 0.81 | SMN1; SMN2 (0.74) | ALDH1A1MAPTHTTSMN1; SMN2CYP2C19 | |
| SCHEMBL15919336 | 0.78 | ALDH1A1 (0.76) | ALDH1A1MAPTHTTSMN1; SMN2HPGD | |
| SCHEMBL17949727 | 0.78 | SMN1; SMN2 (0.73) | ALDH1A1MAPTHTTSMN1; SMN2CYP2C19 | |
| SCHEMBL15919335 | 0.75 | NOTUM (0.71) | ALDH1A1MAPTHTTSMN1; SMN2POLB | |
| SCHEMBL28604247 | 0.69 | HSD17B10 (0.56) | ALDH1A1MAPTHTTSMN1; SMN2CYP2C19 | |
| SCHEMBL5820722 | 0.69 | NOTUM (0.67) | ALDH1A1MAPTHTTSMN1; SMN2CYP2C19 | |
| SCHEMBL11458707 | 0.69 | ALDH1A1 (0.48) | ALDH1A1MAPTSMN1; SMN2CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014116228-A1 | USP14 INHIBITORS FOR TREATING OR PREVENTING VIRAL INFECTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-07-31 | — | — | WO | disclosed |