SCHEMBL15920183

SCHEMBL15920183

CCOc1ccc(NC(=O)C2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1

nearest known ligand 0.64

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.64
LMNA P02545 2/20 0.64
HSD17B10 Q99714 1/20 0.63
NPY2R P49146 1/20 0.63
GAA P10253 2/20 0.61
ALDH1A1 P00352 1/20 0.61
KMT2A Q03164 3/20 0.56
MEN1 O00255 2/20 0.56
DRD3 P35462 1/20 0.56
POLB P06746 2/20 0.54
MGLL Q99685 1/20 0.53
PABPC1 P11940 1/20 0.53
RXFP1 Q9HBX9 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15920163 0.82 NPY2R (0.76) MAPTNPY2RKMT2AMEN1POLB
SCHEMBL15920175 0.78 NPY2R (0.52) MAPTLMNANPY2RGAAALDH1A1
SCHEMBL15919866 0.77 NPY2R (1.00) MAPTLMNANPY2RGAAALDH1A1
SCHEMBL13597023 0.77 OPRD1 (0.58) MAPTLMNAGAAALDH1A1KMT2A
SCHEMBL18193223 0.76 LMNA (0.68) MAPTLMNAHSD17B10GAAKMT2A
SCHEMBL18658138 0.76 MAPT (0.67) MAPTLMNAHSD17B10GAAALDH1A1
SCHEMBL18193496 0.75 MAPT (0.67) MAPTLMNAHSD17B10GAAALDH1A1
SCHEMBL8473671 0.74 KDM4E (0.67) MAPTHSD17B10ALDH1A1KMT2AMEN1
SCHEMBL1552694 0.74 RAB9A (0.61) LMNAALDH1A1KMT2AMEN1POLB
SCHEMBL15919890 0.73 NPY2R (0.56) MAPTLMNANPY2RGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014116684-A1 NON-PEPTIDIC NEUROPEPTIDE Y RECEPTOR MODULATORS ROBERTS EDWARD (US) 2014-07-31 WO disclosed