Sugi Predict

Sugi Predict / Compounds / SCHEMBL15920408

SCHEMBL15920408

SCHEMBL15920408

COC(=O)c1cc(C(F)(F)F)c(C(F)(F)F)cc1C(=O)OC

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CFTR P13569 6/20 0.57
▸ NOTUM Q6P988 3/20 0.51
▸ SOS1 Q07889 1/20 0.46
▸ MAPT P10636 2/20 0.43
▸ CA12 O43570 2/20 0.42
▸ CA1 P00915 2/20 0.42
▸ CA2 P00918 2/20 0.42
▸ CA7 P43166 2/20 0.42
▸ CA9 Q16790 2/20 0.42
▸ CA14 Q9ULX7 2/20 0.42
▸ CES2 O00748 1/20 0.42
▸ PDK2 Q15119 1/20 0.42
▸ PDK4 Q16654 1/20 0.42
▸ KDM4E B2RXH2 2/20 0.41
▸ LMNA P02545 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ GAA P10253 2/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ GLA P06280 1/20 0.40
▸ HPGD P15428 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3874597 0.88 CFTR (0.51) CFTRNOTUMSOS1MAPTCA12
SCHEMBL7595297 0.83 CFTR (0.50) CFTRNOTUMSOS1MAPTCA12
SCHEMBL8102763 0.81 CFTR (0.49) CFTRNOTUMSOS1MAPTKDM4E
SCHEMBL1763845 0.81 CFTR (0.49) CFTRNOTUMSOS1CA12CA1
SCHEMBL23526150 0.81 NOTUM (0.55) CFTRNOTUMSOS1MAPTLMNA
SCHEMBL24983697 0.80 CFTR (0.51) CFTRNOTUMSOS1MAPTCA12
SCHEMBL167743 0.80 CFTR (0.48) CFTRNOTUMSOS1CA12CA1
SCHEMBL7079463 0.80 CFTR (0.48) CFTRNOTUMSOS1MAPTKDM4E
SCHEMBL70873 0.79 CFTR (0.50) CFTRNOTUMSOS1MAPTKDM4E
SCHEMBL22453008 0.79 CFTR (0.67) CFTRNOTUMMAPTKDM4ETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2948147-B1 N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS H LUNDBECK AS (DK) 2019-03-13 — — EP disclosed
US-10195186-B2 N-substituted-5-substituted phthalamic acids as sortilin inhibitors H. LUNDBECK A/S (DK) 2019-02-05 — — US disclosed
US-20170239226-A1 N-Substituted-5-Substituted Phthalamic Acids as Sortilin Inhibitors H. LUNDBECK A/S (DK) 2017-08-24 — — US disclosed
US-9682967-B2 N-substituted-5-substituted phthalamic acids as sortilin inhibitors H. LUNDBECK A/S (DK) 2017-06-20 — — US disclosed
US-20150368231-A1 N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS H. LUNDBECK A/S (DK) 2015-12-24 — — US disclosed
WO-2014114779-A1 N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS H. LUNDBECK A/S (DK) 2014-07-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150368231-A1 N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS SORT1, NRP1, SELPLG CFTR 4673/4885NOTUM 379/4885SOS1 4044/4885
US-10195186-B2 N-substituted-5-substituted phthalamic acids as sortilin inhibitors SORT1, NRP1, SELPLG CFTR 4567/4885NOTUM 548/4885SOS1 3609/4885
US-20170239226-A1 N-Substituted-5-Substituted Phthalamic Acids as Sortilin Inhibitors SORT1, NRP1, SELPLG CFTR 4567/4885NOTUM 548/4885SOS1 3609/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.