Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69740 | 0.80 | NR4A2 (0.48) | CFTRNR4A2CREBBPMAPTTSHR | |
| SCHEMBL2185981 | 0.79 | KDM4E (0.53) | MAPTTSHRLMNAKDM4ECACNA1C | |
| SCHEMBL15920408 | 0.79 | CFTR (0.57) | CFTRNOTUMSOS1MAPTTSHR | |
| SCHEMBL4659258 | 0.78 | GAA (0.40) | CFTRLMNAKDM4EGAAPKM | |
| SCHEMBL10428536 | 0.77 | NOTUM (0.46) | NOTUMKDM4ECYP1A2MEN1KMT2A | |
| SCHEMBL20606230 | 0.77 | CFTR (0.48) | CFTRNOTUMNR4A2CREBBPMAPT | |
| SCHEMBL45490 | 0.74 | LMNA (0.59) | CFTRNOTUMMAPTTSHRLMNA | |
| SCHEMBL3563589 | 0.74 | MAPT (0.55) | CFTRNR4A2CREBBPMAPTTSHR | |
| SCHEMBL24983697 | 0.73 | CFTR (0.51) | CFTRNOTUMSOS1MAPTTSHR | |
| SCHEMBL4925877 | 0.73 | CFTR (0.47) | CFTRNOTUMSOS1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297110-B1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | MERCK SHARP & DOHME (NL) | 2015-05-20 | — | — | EP | disclosed |
| EP-2297110-B1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | MERCK SHARP & DOHME (NL) | 2015-05-20 | — | — | EP | disclosed |
| EP-2209791-B1 | Heterocyclic derivatives | MERCK SHARP & DOHME (NL) | 2014-01-22 | — | — | EP | disclosed |
| EP-2209791-B1 | Heterocyclic derivatives | MERCK SHARP & DOHME (NL) | 2014-01-22 | — | — | EP | disclosed |
| US-8536214-B2 | Indane derivatives as AMPA receptor modulators | N.V. ORGANON (NL) | 2013-09-17 | — | — | US | disclosed |
| US-8536214-B2 | Indane derivatives as AMPA receptor modulators | N.V. ORGANON (NL) | 2013-09-17 | — | — | US | disclosed |
| US-8536214-B2 | Indane derivatives as AMPA receptor modulators | N.V. ORGANON (NL) | 2013-09-17 | — | — | US | disclosed |
| US-8129397-B2 | Substituted thieno[2,3-d]pyrimidines as AMPA modulators | MSD OSS B.V. (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129397-B2 | Substituted thieno[2,3-d]pyrimidines as AMPA modulators | MSD OSS B.V. (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129397-B2 | Substituted thieno[2,3-d]pyrimidines as AMPA modulators | MSD OSS B.V. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110092539-A1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | N.V. ORGANON (NL) | 2011-04-21 | — | — | US | disclosed |
| US-20110092539-A1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | N.V. ORGANON (NL) | 2011-04-21 | — | — | US | disclosed |
| US-20110092539-A1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | N.V. ORGANON (NL) | 2011-04-21 | — | — | US | disclosed |
| WO-2009147167-A1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | N.V. ORGANON (NL) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009062930-A1 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON (NL) | 2009-05-22 | — | — | WO | disclosed |
| US-20090131455-A1 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON | 2009-05-21 | — | — | US | disclosed |
| US-20090131455-A1 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON | 2009-05-21 | — | — | US | disclosed |
| US-20090131455-A1 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131455-A1 | HETEROCYCLIC DERIVATIVES | GRIN2C, GRIK5, GRIN1 | CFTR 1904/4885NOTUM 1664/4885SOS1 1802/4885 |
| US-20110092539-A1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | GRIK5, GRIN3A, GRIK2 | CFTR 1251/4885NOTUM 1622/4885SOS1 2498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.