Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 6/20 | 0.38 |
| ▸ | FNTB | P49356 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13859570 | 0.84 | FNTA (0.40) | KDM4EALOX15RAB9AFNTAFNTB | |
| SCHEMBL3405501 | 0.77 | ALDH1A1 (0.40) | KDM4ESMN1; SMN2MEN1NPC1MITF | |
| SCHEMBL9751048 | 0.76 | KDM4E (0.33) | KDM4EALOX15SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL28294332 | 0.73 | ALDH1A1 (0.39) | KDM4EALOX15SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL15922198 | 0.73 | LMNA (0.42) | ALDH1A1FNTAFNTBLMNA | |
| SCHEMBL15921387 | 0.72 | LMNA (0.41) | ALDH1A1FNTAFNTBLMNA | |
| SCHEMBL28246242 | 0.71 | MEN1 (0.48) | KDM4ESMN1; SMN2MEN1NPC1MITF | |
| SCHEMBL10585916 | 0.70 | ALDH1A1 (0.39) | KDM4EALOX15SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL30082456 | 0.70 | AKR1B1 (0.34) | KDM4EALOX15ALDH1A1LMNA | |
| SCHEMBL28911440 | 0.70 | AKR1B1 (0.34) | KDM4EALOX15ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-A1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014120748-A1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-08-07 | — | — | WO | disclosed |