Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21766656 | 0.85 | NAMPT (0.47) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15910526 | 0.85 | HTT (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL19151107 | 0.82 | TYK2 (0.50) | GSK3BALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31703164 | 0.82 | ALDH1A1 (0.43) | EGFRALDH1A1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL15205400 | 0.81 | GRM5 (0.44) | NPC1RAB9ASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL14791559 | 0.79 | TSHR (0.62) | TSHREGFRERBB3BCHEGSK3B | |
| SCHEMBL15940624 | 0.79 | ALDH1A1 (0.44) | TSHREGFRERBB3ALDH1A1NPC1 | |
| SCHEMBL8434070 | 0.79 | RAB9A (0.67) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15940629 | 0.79 | BCHE (0.53) | TSHREGFRERBB3BCHEALDH1A1 | |
| SCHEMBL19116805 | 0.78 | SMN1; SMN2 (0.51) | RAB9ASMN1; SMN2HCRTR1HCRTR2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014122065-A1 | 2-AMINOPYRIDINE DERIVATIVES AS PLANT GROWTH REGULATING COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-14 | — | — | WO | disclosed |
| WO-2014122065-A1 | 2-AMINOPYRIDINE DERIVATIVES AS PLANT GROWTH REGULATING COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-14 | — | — | WO | disclosed |
| EP-2762468-A1 | 2-aminopyridine derivatives as plant growth regulating compounds | Syngenta Participations AG. (CH) | 2014-08-06 | — | — | EP | disclosed |