Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10288611 | 0.82 | KMT2A (0.41) | SIGMAR1KMT2ALMNASMN1; SMN2STAT6 | |
| SCHEMBL622987 | 0.81 | KMT2A (0.45) | SIGMAR1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL15925470 | 0.80 | LMNA (0.39) | SIGMAR1KMT2ALMNASMN1; SMN2STAT6 | |
| SCHEMBL623034 | 0.77 | SIGMAR1 (0.44) | SIGMAR1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL15925461 | 0.73 | ALOX15 (0.52) | SIGMAR1KMT2ALMNASMN1; SMN2STAT6 | |
| SCHEMBL623813 | 0.71 | EGFR (0.43) | KMT2ALMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL624274 | 0.71 | KMT2A (0.44) | SIGMAR1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10288140 | 0.71 | KMT2A (0.44) | SIGMAR1KMT2ALMNASMN1; SMN2STAT6 | |
| SCHEMBL10298576 | 0.70 | ALOX15 (0.45) | KMT2ASMN1; SMN2ALDH1A1KDM4EALOX15 | |
| SCHEMBL10298367 | 0.69 | KMT2A (0.42) | SIGMAR1KMT2ALMNASMN1; SMN2STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796268-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |