Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15925477 | 0.77 | SIGMAR1 (0.43) | SIGMAR1ARKMT2APIK3CDPIK3CB | |
| SCHEMBL10288611 | 0.74 | KMT2A (0.41) | SIGMAR1ARKMT2APIK3CDPIK3CB | |
| SCHEMBL622987 | 0.73 | KMT2A (0.45) | SIGMAR1KMT2APIK3CDPIK3CBPIK3CA | |
| SCHEMBL624274 | 0.65 | KMT2A (0.44) | SIGMAR1KMT2APIK3CDPIK3CBPIK3CA | |
| SCHEMBL10288140 | 0.65 | KMT2A (0.44) | SIGMAR1KMT2APIK3CDPIK3CBPIK3CA | |
| SCHEMBL15925461 | 0.64 | ALOX15 (0.52) | SIGMAR1ARKMT2APIK3CDPIK3CB | |
| SCHEMBL5618352 | 0.64 | SMN1; SMN2 (0.71) | SIGMAR1KMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL9864307 | 0.63 | MAPT (0.65) | SIGMAR1KMT2ALMNACNR2ALDH1A1 | |
| SCHEMBL10288425 | 0.63 | ALOX15 (0.50) | SIGMAR1ARKMT2APIK3CDPIK3CB | |
| SCHEMBL627094 | 0.63 | AR (0.51) | SIGMAR1ARKMT2APIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603214-A1 | HETEROARYLS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021696-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |