Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15926907 | 0.82 | P2RX7 (0.41) | P2RX7DPP4 | |
| SCHEMBL1638008 | 0.71 | P2RX7 (0.60) | P2RX7CHRNB2CHRNA4DPP4OPRM1 | |
| SCHEMBL15925961 | 0.68 | SMN1; SMN2 (0.51) | ALDH1A1 | |
| SCHEMBL1636802 | 0.65 | P2RX7 (0.55) | P2RX7CHRNB2CHRNA4DPP4PIK3CA | |
| SCHEMBL21198026 | 0.62 | OPRM1 (0.48) | P2RX7CHRNB2CHRNA4DPP4OPRM1 | |
| SCHEMBL26840853 | 0.61 | P2RX7 (0.39) | P2RX7GRIN2BALDH1A1 | |
| SCHEMBL29741499 | 0.61 | SMN1; SMN2 (0.65) | CHRNB2CHRNA4OPRM1OPRL1CHRNB4 | |
| SCHEMBL1441410 | 0.61 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3PDE5A | |
| SCHEMBL7614154 | 0.61 | CHRNB2 (0.45) | P2RX7CHRNB2CHRNA4DPP4OPRM1 | |
| SCHEMBL7614159 | 0.61 | CHRNB2 (0.45) | P2RX7CHRNB2CHRNA4DPP4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796272-B2 | Glycine transporter-inhibiting substances | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2014-08-05 | — | — | US | disclosed |
| US-8796272-B2 | Glycine transporter-inhibiting substances | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2014-08-05 | — | — | US | disclosed |