Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12413958 | 0.81 | ATM (0.46) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL12593915 | 0.81 | TDP1 (0.52) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL397387 | 0.79 | ATM (0.50) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL29805163 | 0.79 | TDP1 (0.50) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL187542 | 0.79 | TDP1 (0.50) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL5953091 | 0.79 | TSHR (0.49) | TDP1ALDH1A1MEN1KMT2APDK1 | |
| SCHEMBL10673642 | 0.79 | GPR35 (0.44) | TDP1ALDH1A1HIF1AMEN1RAB9A | |
| SCHEMBL13395143 | 0.78 | TDP1 (0.42) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL26137537 | 0.78 | PDK1 (0.44) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL57522 | 0.77 | ALOX15 (0.46) | TDP1ATMESPL1ALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160075724-A1 | CETP Inhibitors | MERCK SHARP & DOHME (US) | 2016-03-17 | — | — | US | disclosed |
| US-20140221383-A1 | CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221383-A1 | CETP INHIBITORS | CETP, APOB, MTTP | TDP1 1006/4885ATM 1904/4885ESPL1 3416/4885 |
| US-20160075724-A1 | CETP Inhibitors | CETP, APOB, MTTP | TDP1 1006/4885ATM 1904/4885ESPL1 3416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.