Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | TACR2 | P21452 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SHBG | P04278 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TST | Q16762 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15935902 | 0.98 | ESR1 (0.50) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL15921399 | 0.90 | CA2 (0.47) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL15921243 | 0.88 | CA2 (0.48) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Bromide SCHEMBL9670755 | 0.84 | CHRNB2 (0.46) | KDM4EALDH1A1LMNACYP3A4CHRM2 | |
| SCHEMBL15935890 | 0.83 | SPHK1 (0.46) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Bromide SCHEMBL9671965 | 0.82 | CHRNB2 (0.47) | KDM4EALDH1A1LMNACHRM2CHRM5 | |
| Iodide SCHEMBL15923871 | 0.81 | SPHK1 (0.45) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL15935904 | 0.81 | SPHK1 (0.59) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Iodide SCHEMBL15924663 | 0.80 | SPHK1 (0.58) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL18917600 | 0.80 | CHRNA7 (0.48) | KDM4EALDH1A1LMNACYP3A4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170312249-A1 | MODULATORS OF 14-3-3 FUNCTIONALITY AND USES THEREOF | UNIVERSITY OF SOUTH AUSTRALIA (AU) | 2017-11-02 | — | — | US | disclosed |
| WO-2014118556-A2 | SELECTIVE INHIBITORS AND ALLOSTERIC ACTIVATORS OF SPHINGOSINE KINASE | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2014-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170312249-A1 | MODULATORS OF 14-3-3 FUNCTIONALITY AND USES THEREOF | YWHAH, YWHAG, YWHAB | ESR1 4271/4885ADRA2A 4651/4885ADORA3 4060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.