Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | RYR2 | Q92736 | 4/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31093171 | 0.79 | HTR1A (0.84) | HTR1ADRD2HTR2AHTR7DRD3 | |
| SCHEMBL13622143 | 0.79 | RYR2 (0.60) | ALDH1A1KMT2ARYR2MAPT | |
| SCHEMBL31093179 | 0.77 | KMT2A (0.71) | HTR1ASLC6A4ALDH1A1KMT2AGFER | |
| SCHEMBL13622141 | 0.75 | RYR2 (0.55) | ALDH1A1KMT2ARYR2 | |
| SCHEMBL16026463 | 0.75 | KMT2A (0.83) | HTR1ASLC6A4ALDH1A1KMT2AGFER | |
| SCHEMBL9035245 | 0.75 | KMT2A (0.62) | HTR1ASLC6A4ALDH1A1KMT2AGFER | |
| SCHEMBL10623034 | 0.74 | DRD3 (0.59) | HTR1ADRD2HTR2AHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL7934846 | 0.73 | KMT2A (0.83) | HTR1ASLC6A4ALDH1A1KMT2AGFER | |
| SCHEMBL6867057 | 0.73 | RYR2 (0.51) | HTR2AHTR2BKMT2ARYR2SIGMAR1 | |
| SCHEMBL15936060 | 0.72 | ALDH1A1 (0.58) | ALDH1A1RYR2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2764867-A1 | Agents for preventing and treating disorders Involving modulation of the RYR receptors | The Trustees of Columbia University in the City of New York (US) | 2014-08-13 | — | — | EP | claimed |