SCHEMBL15937786

SCHEMBL15937786

Brc1ccc2c(c1)C(C1c3ccccc3-c3ccc(-c4nc(-c5ccccc5)nc(-c5ccccc5)n4)cc31)c1ccccc1-2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.44
CYP1A2 P05177 2/20 0.44
NR1H4 Q96RI1 1/20 0.39
RAB9A P51151 4/20 0.37
ALDH1A1 P00352 3/20 0.37
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
NPC1 O15118 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
MAPT P10636 3/20 0.37
HPGD P15428 2/20 0.37
NFKB1 P19838 2/20 0.37
NFKB2 Q00653 2/20 0.37
RELA Q04206 2/20 0.37
DGAT1 O75907 1/20 0.37
NR1H2 P55055 1/20 0.37
NR1H3 Q13133 1/20 0.37
TSHR P16473 3/20 0.35
CYP1A1 P04798 1/20 0.35
CYP1B1 Q16678 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15937776 0.80 ABCG2 (0.40) RAB9AALDH1A1MEN1KMT2ANPC1
SCHEMBL20886295 0.77 MEN1 (0.49) MAPK1ALDH1A1MEN1KMT2AMAPT
SCHEMBL14675131 0.75 AHR (0.39) MAPK1ALDH1A1KMT2ASMN1; SMN2HPGD
SCHEMBL15937787 0.74 CYP1A2 (0.50) MAPK1CYP1A2ALDH1A1MEN1KMT2A
SCHEMBL31642820 0.73 NPC1 (0.49) MAPK1CYP1A2NR1H4RAB9AALDH1A1
SCHEMBL19637770 0.73 CYP11B1 (0.54) MAPK1CYP1A2NR1H4RAB9AALDH1A1
SCHEMBL30427162 0.73 CYP11B1 (0.54) MAPK1CYP1A2NR1H4RAB9AALDH1A1
SCHEMBL15394922 0.73 NPC1 (0.56) MAPK1CYP1A2NR1H4RAB9AALDH1A1
SCHEMBL31643003 0.73 L3MBTL1 (0.45) MAPK1NR1H4RAB9AALDH1A1MEN1
SCHEMBL2627622 0.72 ALDH1A1 (0.67) MAPK1CYP1A2NR1H4RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9780311-B2 Compounds for electronic devices MERCK PATENT GMBH (DE) 2017-10-03 US disclosed
US-20140225040-A1 COMPOUNDS FOR ELECTRONIC DEVICES MERCK PATENT GMBH PATENTS & SCIENTIFIC INFORMATION (DE) 2014-08-14 US disclosed