Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24599388 | 0.86 | ALDH1A1 (0.48) | ALDH1A1HPGDNPC1RAB9ALMNA | |
| SCHEMBL24599484 | 0.84 | ALDH1A1 (0.46) | ALDH1A1HPGDNPC1RAB9ALMNA | |
| SCHEMBL4205644 | 0.69 | ALDH1A1 (0.49) | ALDH1A1HPGDNPC1RAB9ALMNA | |
| SCHEMBL24599434 | 0.68 | PSEN1 (0.41) | POLBSMN1; SMN2TSHRPSEN1PSEN2 | |
| SCHEMBL48387 | 0.67 | ALDH1A1 (0.53) | ALDH1A1HPGDNPC1RAB9APIK3CG | |
| SCHEMBL24599347 | 0.67 | PSEN1 (0.41) | NPC1RAB9ASMN1; SMN2TSHRPSEN1 | |
| SCHEMBL1062484 | 0.64 | ALDH1A1 (0.61) | ALDH1A1HPGDNPC1RAB9ALMNA | |
| SCHEMBL3585209 | 0.62 | ALDH1A1 (0.64) | ALDH1A1HPGDNPC1RAB9ALMNA | |
| SCHEMBL8811568 | 0.62 | PIK3CG (0.56) | ALDH1A1HPGDPIK3CGPI4KBPIK3CD | |
| SCHEMBL9570975 | 0.61 | ALDH1A1 (0.50) | ALDH1A1HPGDNPC1RAB9APIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150561-B2 | Thiazole derivatives and use thereof | MERCK SERONO S.A. (CH) | 2015-10-06 | — | — | US | disclosed |
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO S.A. (CH) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | PF4, TEC, PDGFRB | ALDH1A1 234/4885HPGD 957/4885NPC1 3795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.