Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15940088 | 0.88 | MAPT (0.67) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL14975744 | 0.86 | PRKCZ (0.68) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL15940251 | 0.86 | IKBKB (0.56) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL15940253 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL1883906 | 0.86 | ALDH1A1 (0.66) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL24128292 | 0.84 | ALDH1A1 (0.51) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL15940127 | 0.84 | ALDH1A1 (0.74) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL15940360 | 0.82 | ALDH1A1 (0.70) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL3995640 | 0.82 | ALDH1A1 (0.76) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL15940164 | 0.81 | SLC6A3 (0.58) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260448-B2 | Thienopyrimidinone derivatives as mGluR1 antagonists | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-02-16 | — | — | US | disclosed |
| US-20140228565-A1 | THIENOPYRIMIDINONE DERIVATIVES AS mGluR1 ANTAGONISTS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228565-A1 | THIENOPYRIMIDINONE DERIVATIVES AS mGluR1 ANTAGONISTS | GRM1, GRIN1, GRM2 | KDM4E 4008/4885CYP1A2 3437/4885CYP2D6 1789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.