Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | PRKCZ | Q05513 | 8/20 | 0.57 |
| ▸ | PRKCI | P41743 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15939770 | 0.82 | KDM4E (0.53) | ALDH1A1MAPTHSD17B10MAPK1HPGD | |
| SCHEMBL15940127 | 0.82 | ALDH1A1 (0.74) | ALDH1A1MAPTHSD17B10MAPK1HPGD | |
| SCHEMBL15940088 | 0.80 | MAPT (0.67) | ALDH1A1MAPTHSD17B10MAPK1HPGD | |
| SCHEMBL15940164 | 0.80 | SLC6A3 (0.58) | ALDH1A1MAPTHSD17B10MAPK1HPGD | |
| SCHEMBL8187620 | 0.79 | KDM4E (0.51) | ALDH1A1MAPTHSD17B10MAPK1HPGD | |
| SCHEMBL15940251 | 0.78 | IKBKB (0.56) | ALDH1A1MAPTHSD17B10MAPK1HPGD | |
| SCHEMBL14975744 | 0.78 | PRKCZ (0.68) | ALDH1A1MAPTHSD17B10MAPK1HPGD | |
| SCHEMBL5880332 | 0.78 | HSD17B10 (0.52) | ALDH1A1MAPTHSD17B10MAPK1HPGD | |
| SCHEMBL15940253 | 0.78 | KDM4E (0.56) | ALDH1A1MAPTHSD17B10MAPK1HPGD | |
| SCHEMBL1883906 | 0.78 | ALDH1A1 (0.66) | ALDH1A1MAPTHSD17B10MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260448-B2 | Thienopyrimidinone derivatives as mGluR1 antagonists | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-02-16 | — | — | US | disclosed |
| US-20140228565-A1 | THIENOPYRIMIDINONE DERIVATIVES AS mGluR1 ANTAGONISTS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228565-A1 | THIENOPYRIMIDINONE DERIVATIVES AS mGluR1 ANTAGONISTS | GRM1, GRIN1, GRM2 | ALDH1A1 531/4885MAPT 224/4885HSD17B10 2492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.