Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25551811 | 0.87 | RPS6KA5 (0.47) | NPC1MAPTADORA2AMBNL1L3MBTL1 | |
| SCHEMBL30036735 | 0.87 | RPS6KA5 (0.47) | NPC1MAPTADORA2AMBNL1L3MBTL1 | |
| SCHEMBL25552004 | 0.84 | MBNL1 (0.51) | NPC1MAPTADORA2AMBNL1PIN1 | |
| SCHEMBL18416746 | 0.84 | MAPT (0.40) | MAPTL3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL28774690 | 0.84 | MAPT (0.40) | NPC1MAPTADORA2AL3MBTL1PIN1 | |
| SCHEMBL25559456 | 0.84 | NPC1 (0.40) | NPC1MAPTADORA2AMBNL1L3MBTL1 | |
| SCHEMBL20448204 | 0.83 | AR (0.36) | NPC1MAPTL3MBTL1PIN1KMT2A | |
| SCHEMBL1263981 | 0.81 | RPS6KA5 (0.43) | NPC1MAPTL3MBTL1KMT2ARPS6KA5 | |
| SCHEMBL7253389 | 0.80 | ALDH1A1 (0.50) | NPC1ADORA2AL3MBTL1PIN1ADORA1 | |
| SCHEMBL3758203 | 0.79 | KDM4E (0.52) | NPC1MAPTADORA2AL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133171-B2 | Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-09-15 | — | — | US | disclosed |
| US-9108926-B2 | Disubstituted 5-fluoro-pyrimidines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-08-18 | — | — | US | disclosed |
| US-20150005329-A1 | DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-01-01 | — | — | US | disclosed |
| US-20140228387-A1 | DISUBSTITUTED 5-FLUORO-PYRIMIDINES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228387-A1 | DISUBSTITUTED 5-FLUORO-PYRIMIDINES | DPYD, DHFR, TYMP | NPC1 635/4885MAPT 3731/4885ADORA2A 1033/4885 |
| US-20150005329-A1 | DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | DHFR, DPYD, TYMP | NPC1 3274/4885MAPT 4755/4885ADORA2A 1304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.