Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30887532 | 0.85 | ALDH1A1 (0.65) | ALDH1A1TRPA1SMN1; SMN2LMNAGAA | |
| SCHEMBL16731052 | 0.80 | ALDH1A1 (0.51) | ALDH1A1TRPA1SMN1; SMN2LMNAGAA | |
| SCHEMBL6426049 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TRPA1SMN1; SMN2LMNAGAA | |
| 2-(Phenylamino)Cyclohexanol SCHEMBL432133 | 0.76 | ALDH1A1 (0.51) | ALDH1A1TRPA1SMN1; SMN2LMNAGAA | |
| SCHEMBL4065548 | 0.76 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL4064618 | 0.76 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNAGAA | |
| 2-(Phenylamino)Cyclohexanol SCHEMBL432132 | 0.76 | ALDH1A1 (0.51) | ALDH1A1TRPA1SMN1; SMN2LMNAGAA | |
| SCHEMBL7020150 | 0.76 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL4064611 | 0.76 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL7634555 | 0.76 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNAGAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133120-B2 | Fentanyl derivatives as pH-dependent opioid receptor agonists | Charité—Universitätsmedizin Berlin (DE) | 2015-09-15 | — | — | US | disclosed |
| US-20140228406-A1 | FENTANYL DERIVATIVES AS PH-DEPENDENT OPIOID RECEPTOR AGONISTS | KONRAD-ZUSE-INSTITUT (DE) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228406-A1 | FENTANYL DERIVATIVES AS PH-DEPENDENT OPIOID RECEPTOR AGONISTS | OGFR, OPRK1, OPRM1 | ALDH1A1 1551/4885TRPA1 23/4885SMN1; SMN2 3338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.