SCHEMBL15946212

SCHEMBL15946212

Cc1ccc(Cl)c(S(=O)(=O)NC(=O)c2cn3cc(C)cc(Cl)c3n2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALKBH2 Q6NS38 2/20 0.41
ALKBH3 Q96Q83 2/20 0.41
FTO Q9C0B1 2/20 0.41
ALKBH5 Q6P6C2 1/20 0.39
PTGS2 P35354 2/20 0.38
PTGS1 P23219 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
POLB P06746 1/20 0.37
HSD17B10 Q99714 1/20 0.37
ALDH1A1 P00352 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
FBP1 P09467 2/20 0.36
FLT1 P17948 3/20 0.36
FLT4 P35916 3/20 0.36
KDR P35968 3/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
KDM4E B2RXH2 1/20 0.35
NPY2R P49146 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15625181 0.89 FLT1 (0.40) ALDH1A1SMN1; SMN2FBP1FLT1FLT4
SCHEMBL2680314 0.88 ALDH1A1 (0.41) ALKBH2ALKBH3FTOALKBH5PTGS2
SCHEMBL15625176 0.83 PTGS2 (0.50) ALKBH2ALKBH3FTOALKBH5PTGS2
SCHEMBL10204192 0.81 PTGS2 (0.35) ALKBH2ALKBH3FTOALKBH5PTGS2
SCHEMBL15625177 0.81 PTGS2 (0.34) ALKBH2ALKBH3FTOALKBH5PTGS2
SCHEMBL17788090 0.80 ALKBH2 (0.40) ALKBH2ALKBH3FTOALKBH5PTGS2
SCHEMBL10264532 0.79 RXFP1 (0.34) ALKBH2ALKBH3FTOALKBH5PTGS2
SCHEMBL15625175 0.79 PTGS2 (0.33) ALKBH3FTOPTGS2PTGS1FLT1
SCHEMBL15625180 0.79 PTGS2 (0.33) PTGS2PTGS1FLT1FLT4KDR
SCHEMBL2680796 0.79 NPC1 (0.39) ALKBH2ALKBH3FTOALKBH5PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170208811-A1 METHOD FOR CONTROLLING PESTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-07-27 US disclosed
US-9040554-B2 Solid forms of nematocidal sulfonamides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-05-26 US disclosed
US-20140228393-A1 SOLID FORMS OF NEMATOCIDAL SULFONAMIDES CORTEVA AGRISCIENCE LLC 2014-08-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140228393-A1 SOLID FORMS OF NEMATOCIDAL SULFONAMIDES MSL1, MLN, ABCG2 ALKBH2 3562/4885ALKBH3 3737/4885FTO 3304/4885
US-20170208811-A1 METHOD FOR CONTROLLING PESTS MLN, CTRL, PIR ALKBH2 2273/4885ALKBH3 1824/4885FTO 1399/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.