Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALB | P02768 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | POLA1 | P09884 | 1/20 | 0.45 |
| ▸ | POLD1 | P28340 | 1/20 | 0.45 |
| ▸ | TYMP | P19971 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15948321 | 0.84 | POLB (0.64) | TK1LMNATSHRALBPKM | |
| SCHEMBL2056644 | 0.83 | LMNA (0.51) | TK1LMNATSHRALBPKM | |
| SCHEMBL30184800 | 0.81 | TK1 (0.57) | TK1LMNATSHRALBPKM | |
| Phosphoric Acid SCHEMBL1445017 | 0.81 | TK1 (0.53) | TK1LMNATSHRALBPKM | |
| SCHEMBL6832174 | 0.81 | TK1 (0.51) | TK1LMNATSHRALBPKM | |
| SCHEMBL29529503 | 0.80 | TK1 (0.53) | TK1LMNATSHRALBPKM | |
| SCHEMBL6831326 | 0.79 | TK1 (0.47) | TK1LMNATSHRALBPKM | |
| SCHEMBL6224634 | 0.79 | TK1 (0.53) | TK1LMNATSHRALBPKM | |
| SCHEMBL30449834 | 0.79 | TYMP (0.49) | TK1LMNATSHRALBPKM | |
| SCHEMBL27599462 | 0.79 | TK1 (0.53) | TK1LMNATSHRALBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964612-B1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LTD (GB) | 2017-02-01 | — | — | EP | disclosed |
| EP-2964612-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | Illumina Cambridge Limited (GB) | 2016-01-13 | — | — | EP | disclosed |
| US-9156987-B2 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2015-10-13 | — | — | US | disclosed |
| US-20150167073-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2015-06-18 | — | — | US | disclosed |
| US-8993784-B2 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2015-03-31 | — | — | US | disclosed |
| US-20140322713-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-10-30 | — | — | US | disclosed |
| WO-2014135221-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LTD (GB) | 2014-09-12 | — | — | WO | disclosed |
| US-20140255917-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-09-11 | — | — | US | disclosed |
| US-8809551-B1 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140322713-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | POLRMT, FBL, POLM | TK1 407/4885LMNA 512/4885TSHR 4779/4885 |
| US-20150167073-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | POLRMT, FBL, POLM | TK1 407/4885LMNA 512/4885TSHR 4779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.