Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.47 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.39 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9790975 | 0.85 | KMT5A (0.42) | CHRNB2CHRNA3CHRNA4CHRNB4KMT5A | |
| SCHEMBL12505797 | 0.83 | KMT5A (0.41) | CHRNB2CHRNA3CHRNA4CHRNB4KMT5A | |
| SCHEMBL13906189 | 0.81 | KMT5A (0.36) | KMT5AL3MBTL3HRH3 | |
| SCHEMBL18017249 | 0.81 | CHRNB2 (0.47) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB3 | |
| SCHEMBL18909241 | 0.80 | CHRNB2 (0.51) | CHRNB2CHRNA3CHRNA4CHRNB4KMT5A | |
| SCHEMBL9345094 | 0.80 | CHRNB2 (0.51) | CHRNB2CHRNA3CHRNA4CHRNB4KMT5A | |
| SCHEMBL14836434 | 0.78 | CHRNB2 (0.44) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB3 | |
| SCHEMBL9343895 | 0.78 | GAA (0.45) | TDP1CHRM1JAK1 | |
| SCHEMBL20744455 | 0.77 | L3MBTL3 (0.46) | KMT5AL3MBTL3CHRM2MEN1CYP2D6 | |
| SCHEMBL34473242 | 0.77 | CHRNB2 (0.43) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181277-B2 | Aminoquinazoline derivatives and their salts and methods of use | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20140228361-A1 | AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228361-A1 | AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE | ABL1, PRKDC, JAK2 | CHRNB2 4023/4885CHRNA3 4057/4885CHRNA4 4598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.