SCHEMBL18909241

SCHEMBL18909241

CCC(=O)N1CC2CCN(C)C2C1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.51
CHRNA3 P32297 3/20 0.51
CHRNA4 P43681 3/20 0.51
CHRNB4 P30926 2/20 0.51
CHRNA7 P36544 2/20 0.51
CHRNB3 Q05901 1/20 0.44
CHRNA6 Q15825 1/20 0.44
KMT5A Q9NQR1 1/20 0.42
ALDH1A1 P00352 1/20 0.38
EPHX2 P34913 9/20 0.37
L3MBTL3 Q96JM7 1/20 0.36
GNAI3 P08754 2/20 0.36
GNAO1 P09471 2/20 0.36
GNAI1 P63096 2/20 0.36
P2RY12 Q9H244 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22030930 0.82 LIPE (0.40) CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7
SCHEMBL9790975 0.80 KMT5A (0.42) CHRNB2CHRNA3CHRNA4CHRNB4KMT5A
SCHEMBL15948708 0.80 CHRNB2 (0.47) CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7
SCHEMBL9343895 0.80 GAA (0.45) ALDH1A1
SCHEMBL12505797 0.79 KMT5A (0.41) CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7
SCHEMBL21765915 0.77 CHRNB2 (0.72) CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7
SCHEMBL21765914 0.77 CHRNB2 (0.72) CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7
SCHEMBL9345094 0.76 CHRNB2 (0.51) CHRNB2CHRNA3CHRNA4CHRNB4KMT5A
SCHEMBL10305034 0.74 CHRNB2 (0.49) CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7
SCHEMBL23343819 0.74 CHRNB2 (0.62) CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3596072-B1 PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF HOFFMANN LA ROCHE (CH) 2022-06-22 EP disclosed
EP-3416967-B1 THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF HOFFMANN LA ROCHE (CH) 2022-02-09 EP disclosed
EP-3380474-B1 JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF HOFFMANN LA ROCHE (CH) 2019-08-21 EP disclosed
WO-2017140825-A1 THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2017-08-24 WO disclosed
WO-2017089390-A1 JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2017-06-01 WO disclosed