Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.61 |
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.54 |
| ▸ | XDH | P47989 | 4/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | CA12 | O43570 | 3/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 3/20 | 0.54 |
| ▸ | CA7 | P43166 | 3/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520210 | 0.83 | NTRK1 (0.53) | APPMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL28621891 | 0.83 | APP (0.49) | APPTRPC5MEN1KMT2AHSP90AA1 | |
| SCHEMBL7572043 | 0.81 | NTRK1 (0.51) | APPTRPC5MEN1KMT2ACYP3A4 | |
| SCHEMBL3270938 | 0.77 | TERT (0.52) | ADORA3HDAC6HDAC8 | |
| SCHEMBL2495022 | 0.77 | TERT (0.54) | MEN1KMT2ACYP3A4MAPTCYP2C9 | |
| Datiscetin SCHEMBL43916 | 0.76 | APP (1.00) | APPTRPC5MEN1KMT2AHSP90AA1 | |
| Datiscetin SCHEMBL29737517 | 0.76 | APP (1.00) | APPTRPC5MEN1KMT2AHSP90AA1 | |
| Datiscetin SCHEMBL30822630 | 0.76 | APP (1.00) | APPTRPC5MEN1KMT2AHSP90AA1 | |
| SCHEMBL15942094 | 0.75 | TOP1 (0.55) | ADORA3BCHEACHE | |
| SCHEMBL15951016 | 0.75 | GAA (0.47) | APPTRPC5MEN1KMT2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9956226-B2 | Methods and compounds for the inhibition of cellular proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-01 | — | — | US | disclosed |
| US-9956226-B2 | Methods and compounds for the inhibition of cellular proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-01 | — | — | US | disclosed |
| US-9956226-B2 | Methods and compounds for the inhibition of cellular proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-01 | — | — | US | disclosed |
| US-20150374707-A1 | Methods and Compounds for the Inhibition of Cellular Proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-12-31 | — | — | US | disclosed |
| US-20150374707-A1 | Methods and Compounds for the Inhibition of Cellular Proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-12-31 | — | — | US | disclosed |
| US-20150374707-A1 | Methods and Compounds for the Inhibition of Cellular Proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-12-31 | — | — | US | disclosed |
| WO-2014124412-A2 | METHODS AND COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150374707-A1 | Methods and Compounds for the Inhibition of Cellular Proliferation | MKI67, PCNA, DDX21 | APP 4608/4885TRPC5 4467/4885MEN1 2600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.