Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | TOP1 | P11387 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15942094 | 0.89 | TOP1 (0.55) | TERTEGFRPDGFRBFGFR1KDR | |
| SCHEMBL28629193 | 0.78 | TOP1 (0.72) | EGFRPDGFRBFGFR1KDRTOP1 | |
| SCHEMBL15950982 | 0.77 | APP (0.61) | HDAC8HDAC6ADORA3 | |
| SCHEMBL28624602 | 0.74 | TOP1 (0.52) | TERTTOP1 | |
| SCHEMBL5076738 | 0.73 | BCL2 (0.52) | — | |
| SCHEMBL7548426 | 0.73 | MAOA (0.60) | ADORA3SIGMAR1 | |
| SCHEMBL9540725 | 0.71 | MEN1 (0.53) | EGFRPDGFRBFGFR1KDR | |
| SCHEMBL433900 | 0.70 | EGFR (0.71) | EGFRKDRSIGMAR1 | |
| SCHEMBL1520210 | 0.70 | NTRK1 (0.53) | EGFR | |
| SCHEMBL16823312 | 0.70 | EGFR (0.70) | EGFRKDRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9956226-B2 | Methods and compounds for the inhibition of cellular proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-01 | — | — | US | disclosed |
| US-9956226-B2 | Methods and compounds for the inhibition of cellular proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-01 | — | — | US | disclosed |
| US-20150374707-A1 | Methods and Compounds for the Inhibition of Cellular Proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-12-31 | — | — | US | disclosed |
| US-20150374707-A1 | Methods and Compounds for the Inhibition of Cellular Proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-12-31 | — | — | US | disclosed |
| WO-2014124412-A2 | METHODS AND COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-08-14 | — | — | WO | disclosed |
| US-7691418-B2 | Composition for inhibiting or preventing the formation of a biofilm | OYSTERSHELL NV (BE) | 2010-04-06 | — | — | US | disclosed |
| US-20070258913-A1 | Composition for Inhibiting or Preventing the Formation of a Biofilm | OYSTERSHELL NV (BE) | 2007-11-08 | — | — | US | disclosed |
| EP-1796656-A2 | COMPOSITION FOR INHIBITING OR PREVENTING THE FORMATION OF A BIOFILM | Oystershell NV (BE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029893-A2 | COMPOSITION FOR INHIBITING OR PREVENTING THE FORMATION OF A BIOFILM | OYSTERSHELL NV (BE) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070258913-A1 | Composition for Inhibiting or Preventing the Formation of a Biofilm | NQO2, NFKBIA, CROCC | TERT 851/4885EGFR 4699/4885PDGFRB 3830/4885 |
| US-20150374707-A1 | Methods and Compounds for the Inhibition of Cellular Proliferation | MKI67, PCNA, DDX21 | TERT 682/4885EGFR 2041/4885PDGFRB 2331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.