Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SCN4A | P35499 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15955789 | 1.00 | HTT (0.69) | HTTNPC1L3MBTL1NPSR1LMNA | |
| SCHEMBL15955947 | 1.00 | HTT (0.69) | HTTNPC1L3MBTL1NPSR1LMNA | |
| SCHEMBL7068303 | 0.81 | NPC1 (0.47) | HTTNPC1L3MBTL1NPSR1LMNA | |
| SCHEMBL28898382 | 0.80 | NPC1 (0.62) | NPC1LMNAMEN1KMT2AGAA | |
| SCHEMBL38658094 | 0.80 | L3MBTL1 (0.58) | NPC1L3MBTL1NPSR1LMNAMEN1 | |
| SCHEMBL9107269 | 0.80 | L3MBTL1 (0.61) | NPC1L3MBTL1NPSR1LMNAMEN1 | |
| SCHEMBL9107258 | 0.80 | L3MBTL1 (0.61) | NPC1L3MBTL1NPSR1LMNAMEN1 | |
| SCHEMBL7411698 | 0.80 | NPC1 (0.61) | HTTNPC1L3MBTL1NPSR1LMNA | |
| SCHEMBL13956980 | 0.80 | NPC1 (0.61) | HTTNPC1L3MBTL1NPSR1LMNA | |
| SCHEMBL2135903 | 0.79 | HTT (0.46) | HTTNPC1L3MBTL1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9868730-B2 | Kappa opioid receptor selective compounds, compositions, and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-01-16 | — | — | US | disclosed |
| US-20160002216-A1 | KAPPA OPIOID RECEPTOR SELECTIVE COMPOUNDS, COMPOSITIONS, AND USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2016-01-07 | — | — | US | disclosed |
| US-20160002216-A1 | KAPPA OPIOID RECEPTOR SELECTIVE COMPOUNDS, COMPOSITIONS, AND USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2016-01-07 | — | — | US | disclosed |
| WO-2014127256-A1 | KAPPA OPIOID RECEPTOR SELECTIVE COMPOUNDS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-08-21 | — | — | WO | disclosed |
| WO-2014127256-A1 | KAPPA OPIOID RECEPTOR SELECTIVE COMPOUNDS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002216-A1 | KAPPA OPIOID RECEPTOR SELECTIVE COMPOUNDS, COMPOSITIONS, AND USES THEREOF | OPRK1, OPRL1, OPRM1 | HTT 2941/4885NPC1 957/4885L3MBTL1 3604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.