Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 6/20 | 0.66 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11145820 | 0.84 | PLK1 (0.66) | PLK1NR1H4EPHX2HDAC2HDAC8 | |
| SCHEMBL14025527 | 0.83 | PLK1 (0.76) | PLK1NR1H4EPHX2HDAC2HDAC8 | |
| SCHEMBL9450034 | 0.82 | PLK1 (0.63) | PLK1NR1H4EPHX2HDAC2HDAC8 | |
| SCHEMBL28501530 | 0.82 | HDAC1 (0.63) | NR1H4EPHX2HDAC2HDAC8HDAC6 | |
| SCHEMBL11681593 | 0.81 | CA2 (0.48) | PLK1NR1H4EPHX2CA2CAMK2A | |
| SCHEMBL659834 | 0.81 | PLK1 (0.68) | PLK1NR1H4EPHX2HDAC2HDAC8 | |
| SCHEMBL15956061 | 0.81 | PLK1 (0.61) | PLK1NR1H4EPHX2HDAC2HDAC8 | |
| SCHEMBL28260509 | 0.80 | PLK1 (0.66) | PLK1NR1H4EPHX2HDAC2HDAC8 | |
| SCHEMBL250247 | 0.80 | HDAC6 (0.80) | PLK1NR1H4EPHX2HDAC2HDAC8 | |
| SCHEMBL3440217 | 0.79 | PLK1 (0.59) | PLK1NR1H4EPHX2HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051193-A1 | COMPOUNDS USEFUL AS CSF1 MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |
| WO-2016051193-A1 | COMPOUNDS USEFUL AS CSF1 MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |
| WO-2014125426-A1 | TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-21 | — | — | WO | disclosed |
| WO-2014125426-A1 | TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-21 | — | — | WO | disclosed |