Indacaterol

Indacaterol

SCHEMBL159597

CCc1cc2c(cc1CC)CC(NCC(O)c1ccc(O)c3[nH]c(=O)ccc13)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB2

The experimentally established mechanism targets of Indacaterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 known ✓ P07550 19/20 1.00
ADRB1 P08588 10/20 1.00
SLC6A2 P23975 1/20 1.00
ADRA1D P25100 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2C P28335 1/20 1.00
SLC6A4 P31645 1/20 1.00
ADRA1A P35348 1/20 1.00
ADRA1B P35368 1/20 1.00
DRD3 P35462 1/20 1.00
SLC6A3 Q01959 1/20 1.00
SRSF6 Q13247 1/20 1.00
CYP1B1 Q16678 1/20 1.00
TMEM97 Q5BJF2 1/20 1.00
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 1/20 0.51
LMNA P02545 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indacaterol SCHEMBL29350045 1.00 ADRB2 (1.00) ADRB2ADRB1SLC6A2ADRA1DHTR2A
Indacaterol SCHEMBL4186345 1.00 ADRB2 (1.00) ADRB2ADRB1SLC6A2ADRA1DHTR2A
Indacaterol SCHEMBL29367297 1.00 ADRB2 (1.00) ADRB2ADRB1SLC6A2ADRA1DHTR2A
Indacaterol SCHEMBL29798949 1.00 ADRB2 (1.00) ADRB2ADRB1SLC6A2ADRA1DHTR2A
Indacaterol SCHEMBL48098 1.00 ADRB2 (1.00) ADRB2ADRB1SLC6A2ADRA1DHTR2A
Indacaterol SCHEMBL867571 0.99 ADRB2 (0.98) ADRB2ADRB1SLC6A2ADRA1DHTR2A
Indacaterol SCHEMBL3664612 0.99 ADRB2 (0.98) ADRB2ADRB1SLC6A2ADRA1DHTR2A
Indacaterol SCHEMBL4012030 0.99 ADRB2 (0.98) ADRB2ADRB1SLC6A2ADRA1DHTR2A
Indacaterol SCHEMBL867570 0.99 ADRB2 (0.98) ADRB2ADRB1SLC6A2ADRA1DHTR2A
Indacaterol SCHEMBL4012026 0.99 ADRB2 (0.98) ADRB2ADRB1SLC6A2ADRA1DHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1399 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240226084-A9 HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS TECHFIELDS PHARMA CO., LTD. (CN) 2024-07-11 US claimed
US-20240131017-A1 HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS TECHFIELDS PHARMA CO., LTD. (CN) 2024-04-25 US claimed
US-20240115562-A1 HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS TECHFIELDS PHARMA CO., LTD. (CN) 2024-04-11 US claimed
US-20210236478-A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists NOVARTIS AG (CH) 2021-08-05 US claimed
EP-3191081-B1 FORMULATION COMPRISING GLYCOPYRROLATE, METHOD AND APPARATUS VECTURA LTD (GB) 2020-03-25 EP claimed
US-20190282561-A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists NOVARTIS AG (CH) 2019-09-19 US claimed
US-20180071276-A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists NOVARTIS AG (CH) 2018-03-15 US claimed
US-20160101097-A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists NOVARTIS AG (CH) 2016-04-14 US claimed
US-9040559-B2 BETA2-adrenoceptor agonists NOVARTIS AG (CH) 2015-05-26 US claimed
US-20150072961-A1 HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS PREMIER RESEARCH INTERNATIONAL, LLC 2015-03-12 US claimed
WO-2006128847-A2 MEDICAMENT CONTAINING A BETAMIMETIC IN CONJUNCTION WITH AN ANTICHOLINERGIC AND A PDE IV INHIBITOR BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-12-07 WO claimed
US-20060270667-A1 NOVEL MEDICAMENT COMBINATIONS FOR THE TREATMENT OF RESPIRATORY DISEASES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-11-30 US claimed
EP-1651270-A1 MEDICAMENTS FOR INHALATION COMPRISING BETAMIMETICS AND AN ANTICHOLINERGIC Boehringer Ingelheim International GmbH (DE) 2006-05-03 EP claimed
EP-1651221-A1 MEDICAMENTS FOR INHALATION COMPRISING BETAMIMETICS AND AN ANTICHOLINERGIC AGENT BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-05-03 EP claimed
US-20060034776-A1 Inhalable medicaments containing a new anticholinergic, corticosteroids, and betamimetics BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-02-16 US claimed
US-20060035893-A1 Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-02-16 US claimed
US-20050107417-A1 Medicaments for inhalation comprising a novel anticholinergic and a betamimetic BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-05-19 US claimed
WO-2005014044-A1 MEDICAMENTS FOR INHALATION COMPRISING BETAMIMETICS AND AN ANTICHOLINERGIC BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-02-17 WO claimed
WO-2005013992-A1 MEDICAMENTS FOR INHALATION COMPRISING BETAMIMETICS AND AN ANTICHOLINERGIC AGENT BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-02-17 WO claimed
US-20050026948-A1 Medicaments for inhalation comprising an anticholinergic and a betamimetic BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-02-03 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060270667-A1 NOVEL MEDICAMENT COMBINATIONS FOR THE TREATMENT OF RESPIRATORY DISEASES ADRB3, CHRM3, ADRB2 ADRB2 3/4885ADRB1 5/4885SLC6A2 681/4885
US-20240226084-A9 HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS HRH4, HCAR2, PAH ADRB2 591/4885ADRB1 445/4885SLC6A2 778/4885
US-20050107417-A1 Medicaments for inhalation comprising a novel anticholinergic and a betamimetic CHRM1, CHRND, ADRA1D ADRB2 6/4885ADRB1 4/4885SLC6A2 483/4885
US-20180071276-A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists ADRB2, GALR2, GALR3 ADRB2 1/4885ADRB1 5/4885SLC6A2 1034/4885
US-20050026948-A1 Medicaments for inhalation comprising an anticholinergic and a betamimetic CHRM1, CHRND, CHRM3 ADRB2 5/4885ADRB1 4/4885SLC6A2 398/4885
US-20160101097-A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists ADRB2, GALR2, GALR3 ADRB2 1/4885ADRB1 5/4885SLC6A2 1021/4885
US-20240115562-A1 HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS HRH4, HCAR2, PAH ADRB2 591/4885ADRB1 445/4885SLC6A2 778/4885
US-20150072961-A1 HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS HRH4, HCAR2, PAH ADRB2 591/4885ADRB1 445/4885SLC6A2 778/4885
US-20210236478-A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists ADRB2, GALR2, GALR3 ADRB2 1/4885ADRB1 5/4885SLC6A2 1020/4885
US-20060034776-A1 Inhalable medicaments containing a new anticholinergic, corticosteroids, and betamimetics ADRB1, ADRB2, ADRB3 ADRB2 2/4885ADRB1 1/4885SLC6A2 562/4885
US-20190282561-A1 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists ADRB2, GALR2, GALR3 ADRB2 1/4885ADRB1 6/4885SLC6A2 987/4885
US-20240131017-A1 HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS HRH4, HCAR2, PAH ADRB2 591/4885ADRB1 445/4885SLC6A2 778/4885
US-20060035893-A1 Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders BDKRB2, EDNRB, GRK5 ADRB2 22/4885ADRB1 107/4885SLC6A2 2993/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.