Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 11/20 | 0.39 |
| ▸ | BCHE | P06276 | 8/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17928601 | 0.89 | MTNR1A (0.47) | MTNR1ACYP1A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL14250228 | 0.85 | MTNR1A (0.46) | MTNR1ACYP1A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL14314428 | 0.84 | MTNR1A (0.45) | MTNR1ACYP1A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL15960991 | 0.82 | CYP1A2 (0.46) | CYP1A2KDM4ECYP3A4CYP2C19HSD17B10 | |
| SCHEMBL12630208 | 0.80 | ALDH1A1 (0.43) | MTNR1ACYP1A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL15305097 | 0.80 | ALDH1A1 (0.43) | MTNR1ACYP1A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL15954932 | 0.80 | MTNR1A (0.42) | MTNR1ACYP1A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL12692905 | 0.80 | MTNR1A (0.36) | MTNR1ACYP1A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL12692897 | 0.80 | PDE5A (0.39) | MTNR1ACYP1A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL15960987 | 0.79 | ACHE (0.41) | CYP1A2KDM4ECYP3A4CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9321788-B2 | Tricyclic antibiotics | BASILEA PHARMACEUTICA AG (CH) | 2016-04-26 | — | — | US | disclosed |
| US-20140235855-A1 | Tricyclic Antibiotics | BASILEA PHARMACEUTICA AG (CH) | 2014-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235855-A1 | Tricyclic Antibiotics | CBR1, CYP2S1, C1S | MTNR1A 276/4885CYP1A2 15/4885KDM4E 4454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.