Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 8/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15965171 | 0.86 | KLKB1 (0.47) | KLKB1CYP19A1CYP11B1CYP11B2RBP4 | |
| SCHEMBL15964744 | 0.84 | RBP4 (0.54) | KLKB1CYP19A1RBP4 | |
| SCHEMBL22048706 | 0.82 | KLKB1 (0.45) | KLKB1CYP19A1CYP11B1CYP11B2RBP4 | |
| SCHEMBL15964746 | 0.81 | NOTUM (0.50) | KLKB1CYP19A1 | |
| SCHEMBL31591084 | 0.81 | USP30 (0.40) | KLKB1GRM2RBP4 | |
| SCHEMBL23189129 | 0.79 | KLKB1 (0.43) | KLKB1CYP19A1CYP11B1CYP11B2RBP4 | |
| SCHEMBL31591070 | 0.79 | ADA (0.40) | KLKB1GRM2RBP4 | |
| SCHEMBL31591086 | 0.79 | GRM2 (0.39) | KLKB1GRM2RBP4 | |
| SCHEMBL9714533 | 0.78 | GRM2 (0.48) | GRM2 | |
| SCHEMBL23188889 | 0.78 | L3MBTL1 (0.48) | KLKB1CYP19A1CYP11B1CYP11B2RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |
| WO-2014125444-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-08-21 | — | — | WO | disclosed |